Results 111 to 120 of about 2,296,541 (319)

Endothelial Function and Physical Exercise

Arquivos Brasileiros de Cardiologia, 2018
O endotelio e considerado um tecido ativo e dinâmico com propriedades importantes como manutencao da circulacao sanguinea, regulacao do tonus vascular, permeabilidade microvascular, sinalizacao e angiogenese vascular e resposta inflamatoria. O endotelio permite a conexao entre componentes da circulacao e sistemas do organismo.
Pagan, Luana Urbano, Gomes, Mariana Janini, Okoshi, Marina Politi   +2 more
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effect of a nutrition supplement and physical activity program on pneumonia and walking capacity in Chilean older people: a factorial cluster randomized trial. [PDF]

, 2011
BACKGROUND: Ageing is associated with increased risk of poor health and functional decline. Uncertainties about the health-related benefits of nutrition and physical activity for older people have precluded their widespread implementation.
Allen, Elizabeth, Allen Elizabeth, Elbourne, Diana, Hugo Sanchez, Aedo Cristian, Fletcher, Olivia, Dangour Alan D., Walker Damian G., Cristian Aedo, Dangour, Alan D, Ricardo Uauy, Fletcher Olivia, Damian G. Walker, Alan D. Dangour, Albala Brevis, Cecilia, Diana Elbourne, Uauy, Ricardo, Uauy Ricardo, Alan D Dangour, Cecilia Albala, Sanchez, Hugo, Walker, Damian G, Dangour, Alan D., Uauy Dagach-Imbarack, Ricardo, Emily Grundy, Grundy Emily, Sanchez Hugo, Elbourne Diana, Aedo, Cristian, Albala Cecilia, Olivia Fletcher, Elizabeth Allen, Grundy, Emily, Walker, Damian G., Albala, Cecilia, Damian G Walker, Walker, Damian   +36 more
core   +1 more source

Effects of repeated sprint exercise on brachial artery shear rate patterns in healthy adults

Physiological Reports
Endothelial cells are influenced by mechanical shear forces from blood flow, which increase considerably during exercise. Exercise‐induced shear stimuli depend on several factors, including intensity and modality; though little is known about the effects
Matthew A. Chatlaong, Lori M. Keys, Matthew B. Jessee   +2 more
doaj   +1 more source

Effect of Mn2+ on Upconversion Emission, Thermal Sensing and Optical Heater Behavior of Yb3+ - Er3+ Codoped NaGdF4 Nanophosphors

Frontiers in Chemistry, 2019
In thiswork, we investigate the influence of Mn2+ on the emission color, thermal sensing and optical heater behavior of NaGdF4: Yb/Er nanophosphors, which the nanoparticles were synthesized by a hydrothermal method using oleic acid as both a stabilizing ...
Qinping Qiang, Qinping Qiang, Yuhua Wang, Yuhua Wang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians [PDF]

Mitochondrial dysfunction and genomic instability are key hallmarks of aging. The aim of this study was to evaluate whether maintenance of physical capacities at very old age is associated with key hallmarks of aging.
Hoei Rasmussen, Signe, Tinna Stevnsner, Signe Hoei Rasmussen, Bohr, Vilhelm A, Bohr, Vilhelm A., Myrup Holst, Camilla, Rasmussen, Signe Høi, Sánchez-Román Rojas, Inés, Christensen, Kaare; id_orcid, Mikael Thinggaard, Sanchez-Roman, Ines, Jonas Mengel-From, Beatriz Ferrando, Holst, Camilla Myrup, Thinggaard, Mikael, Ferrando, Beatriz, Kaare Christensen, Camilla Myrup Holst, Christensen, Kaare, Stevnsner, Tinna V., Mengel-From, Jonas, Stevnsner, Tinna, Vilhelm A. Bohr, Ines Sanchez-Roman, Thinggaard, Mikael; id_orcid   +24 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Physical activity and cognitive function in individuals over 60 years of age: a systematic review

, 2014
Ashley Carvalho,1,2 Irene Maeve Rea,2 Tanyalak Parimon,3,4 Barry J Cusack3,51Department of Public Health, 2School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Northern Ireland, UK; 3Research and Development Service ...
Carvalho A, Parimon T, Cusack BJ, Rea IM
core  

An exploratory assessment of GPT-4o and GPT-4 performance on the Japanese National Dental Examination

Saudi Dental Journal
Background and Objectives: Multiple large language models (LLMs) have been released since 2022, including OpenAI’s GPT-3.5 and GPT-4. The latest model, GPT-4o, introduced on May 13, 2024, significantly improves GPT-4.
Masaki Morishita, Hikaru Fukuda, Shino Yamaguchi, Kosuke Muraoka, Taiji Nakamura, Masanari Hayashi, Izumi Yoshioka, Kentaro Ono, Shuji Awano   +8 more
doaj   +1 more source