Results 41 to 50 of about 5,933,912 (298)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Accelerometry is a valid measure of physical inactivity but not of energy expended on physical activity in people with schizophrenia

, 2006
The relationship between physical inactivity and weight gain, obesity and related co-morbid conditions such as cardiovascular disease and diabetes is well established (Lees and Booth, 2005).
Stedman, Terry J., Sharpe, Jenny-Kay, Byrne, Nuala M., Hills, Andrew P.   +3 more
core   +1 more source

Prevalence and predictors of physical inactivity levels among Kenyan adults (18–69 years): an analysis of STEPS survey 2015

BMC Public Health, 2018
Background Physical inactivity accounts for more than 3 million deaths worldwide, and is implicated in causing 6% of coronary heart diseases, 7% of diabetes, and 10% of colon or breast cancer.
Muthoni Gichu, Gershim Asiki, Pamela Juma, Joseph Kibachio, Catherine Kyobutungi, Elijah Ogola   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Shifting the physical inactivity curve worldwide by closing the gender gap

, 2017
Purpose: The aims of this study were to (i) examine gender differences in physical inactivity in countries with different levels of Human Development Index (HDI); and (ii) assess whether small changes in the prevalence of inactivity in women could ...
Kolbe-Alexander, Tracy L., Grégore I. Mielke, Tracy L. Kolbe-Alexander, da Silva, Inacio Chrochemore M., Inacio Crochemore M. da Silva, Mielke, Gregore I., da Silva, Inacio Crochemore M., Brown, Wendy J., Wendy J. Brown   +8 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Physical inactivity in healthy, obese, and diabetic adults in Germany: An analysis of related socio-demographic variables.

PLoS ONE, 2021
BackgroundAdults with diabetes or obesity are more likely to be physically inactive than healthy adults. Physical activity is essential in the management of both diseases, necessitating targeted interventions in these groups. This study analysed physical
Stephanie Linder, Karim Abu-Omar, Wolfgang Geidl, Sven Messing, Mustafa Sarshar, Anne K Reimers, Heiko Ziemainz   +6 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Indicadores sociodemográficos da atividade física nos seus diferentes domínios em adultos de Florianópolis, Santa Catarina [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2013O objetivo deste trabalho foi explorar a atividade física nos seus diferentes domínios (lazer, deslocamento ...
Del Duca, Giovâni Firpo
core