Results 111 to 120 of about 1,510,047 (309)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MODEL DEVELOPMENT OF PHYSICAL EXERCISE GOALKEEPER OF FOOTBALL WITH CIRCUIT

, 2017
This study aims to develop models of physical exercise soccer goalie by using the circuit method. Research development is packaged in the form of circuit training models to improve the physical condition of football goalkeeper.
Mulyana, Mulyana, Tangkudung, James, Apriliyanto, Rizki   +2 more
core   +1 more source

Experimental Study on the Hydraulic Characteristics and Shape Optimization of Ship Lock Water Conveyance Systems

Journal of Marine Science and Engineering
To enhance the passing capacity of the Bailongtan Ship Lock on the Hongshui River, this study focused on the design scheme of its water conveyance system reconstruction and expansion project.
Yu Duan, Dianguang Ma, Weidong Gan, Chao Ji, Junwei Zhou   +4 more
doaj   +1 more source

PHYSICAL MODELLING AND TESTING OF AN ADVANCED GAS COOLED REACTOR CORE MODEL

, 2017
Advanced Gas Cooled Reactor (AGR) cores are multi-layered arrays of graphite components whose geometry and mechanical properties change under prolonged exposure to neutron irradiation. The presence of cracked components in the arrays later in their operational life may cause disruption of core geometry with implications for fuel cooling and control rod
Oddbjornsson, Olafur, Kloukinas, Panos, Dihoru, Luiza, Dietz, Matthew, Horseman, Tony, Voyagaki, Elia, Crewe, Adam, Taylor, Colin, Steer, Alan   +8 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Physical activity and perceived benefits and barriers in adults aged 55-74

, 2012
In order to increase the number of older adults physically active enough to obtain the health benefits of exercise, inactive individuals must firstly be identified, and attention must then be focused on determinants of exercise amenable to change ...
Montgomery, Alan A.
core  

Settlement Behavior and Deformation Control of Twin Shield Tunneling Beneath an Operating Railway: A Case Study of Qingdao Metro

Buildings
Shield tunneling beneath existing railways remains a critical challenge in urban infrastructure development, as it risks destabilizing overlying soil structures and compromising railway safety.
Yankai Wu, Shixin Wang, Changhui Gao, Wenqiang Li, Yugang Wang, Ruiting Sun   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source