Results 91 to 100 of about 1,450,984 (263)
BuildingsShield tunneling beneath existing railways remains a critical challenge in urban infrastructure development, as it risks destabilizing overlying soil structures and compromising railway safety.
Yankai Wu +5 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
BuildingsIn situ tunnel expansion provides a cost-effective and environmentally sustainable alternative to new tunnel construction. However, staged widening disturbs the lining–rock system, triggering complex, non-monotonic stability responses.
Xiaochuan Han +6 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Development of Similarity Materials for Jointed Rock Masses in Underground Cavern Model Tests
BuildingsUtilizing appropriate similar materials in physical model testing is critical to ensuring an accurate simulation of the prototype mechanical behavior.
Jiawei Zhang +5 more
doaj +1 more source
The Standard Model of Particle Physics: Status and Low-Energy Tests [PDF]
, 2006 Precision measurements of low-energy observables provide stringent tests of the Standard Model structure and accurate determinations of its parameters. An overview of the present experimental status is presented. The main topics discussed are the muon anomalous magnetic moment, the asymptotic freedom of strong interactions, the lepton universality of ...
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Applied SciencesConcentrated rear runoff is an important hydraulic factor that promotes slope instability and flow-like transport characteristics in mountainous landslides; however, the deformation–failure process of slopes and their response relationships under ...
Kun Song, Lei Guo, Qiang Fu, Bo Wen
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Journal of Marine Science and EngineeringSubmarine landslides pose severe marine geological hazards. Their movement and deposition behaviors can seriously threaten marine engineering stability and coastal safety.
Rui Yang, Zili Dai
doaj +1 more source