Results 101 to 110 of about 1,510,047 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Physical and 3D numerical modelling of reinforcements pullout test

Scientific Reports
AbstractThis paper reports results of laboratory and 3D numerical modeled pull-out tests with steel ladders and polymeric strip reinforcements. These types of reinforcement are commonly used in reinforced soil walls constructed with concrete facing elements.
Puig Damians, Ivan, Moncada Ramírez, Aníbal Andrés, Olivella Pastallé, Sebastià, Lloret Morancho, Antonio, Josa Garcia-Tornel, Alejandro   +4 more
openaire   +5 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Physical Model of Rainfall Induced Landslide in Flume Test: Preliminary Results

, 2020
Physical modelling of landslides using scaled landslide models behavior began in 1970s in Japan at a scaled natural slope physical model. The laboratory experiments of landslide behavior in a scaled physical model (also called flume or flume test ...
Peranić, Josip, Arbanas, Željko, Vivoda Prodan, Martina, Pajalić, Sara, Jagodnik, Vedran   +4 more
core  

A central limit theorem for sums of functions of residuals in a high-dimensional regression model with an application to variance homoscedasticity test

, 2017
We establish a joint central limit theorem for sums of squares and the fourth powers of residuals in a high-dimensional regression model. We then apply this CLT to detect the existence of heteroscedasticity for linear regression models without assuming ...
Yanqing Yin, Pan, Guangming, Guangming Pan, Bai, Zhidong, Zhidong Bai, Yin, Yanqing   +5 more
core   +1 more source

Test of a cubic spline interface for physical processes with a 1-D third-order spectral element model [PDF]

, 2019
A common way to introduce physical processes into numerical models of the atmosphere is to call the parameterization at every grid point. This can lead to considerable errors.
J. Li, J. Zhu, Steppeler, J, Li, J, Fang, F, J. Steppeler, F. Fang, Zhu, J   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Experimentally Based Model to Size the Geometry of a New OWC Device, with Reference to the Mediterranean Sea Wave Environment

Energies, 2013
This note presents the Seabreath wave energy converter, basically a multi-chamber floating oscillating water column device, and the lumped model used to size its chambers, the ducts and the turbine.
Piero Ruol, Paolo Pezzutto, Luca Martinelli   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Failure Mechanism of Sandy Soil Slopes Under High-Angle Normal Bedrock-Fault Dislocation: Physical Model Tests

Applied Sciences
Bedrock fault dislocation is a crucial structural factor influencing landslide movement. Accurately predicting the location and scale of rupture zones within a slope body is essential for effective slope construction design and risk mitigation.
Jianke Ma, Jianyi Zhang, Yijie Song, Ziyi Feng, Jing Tian, Jun Gu, Xiaobo Li   +6 more
doaj   +1 more source