Results 111 to 120 of about 28,137,191 (312)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Physical Model of the Reeb Foliation
AxiomsIn this paper, after explaining some basic aspects of the modern theory of foliations with the aim of describing the celebrated Reeb foliation, we propose the first construction of a comprehensive physical model of it. The construction of the model is achieved through an implementation of geometric methods for 3D printing.
Bande, Gianluca, Franzoni, Gregorio
openaire +2 more sources
Process of overburden failure in steeply inclined multi-seam mining: insights from physical modelling. [PDF]
R Soc Open Sci, 2021 Wang H, Qin Y, Wang H, Chen Y, Liu X.
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Validation of numerical model of a liquid flow in a tundish by laboratory measurements
Metalurgija, 2014 The article presents results of physical and numerical modelling of steel flow through a tundish of continuous casting machine. In numerical calculations the influence of mesh density was tested and the correctness of the flow description in the near ...
T. Merder +3 more
doaj
Experimental Study of Ground Subsidence Mechanism Caused by Sewer Pipe Cracks
Applied Sciences, 2018 Simultaneous leakage of soil particles and groundwater into underground vacant spaces caused by sewer pipe defects and cracks can cause underground cavities and even ground collapse on the surface.
Tarek Karoui +3 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Metalurgija, 2015 Today there are many reactors used in refining of primary and secondary aluminium. Continuous reactor URC-7000 is one of them. The model of such reactor was built at 1:3 scale.
M. Saternus, T. Merder
doaj
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source