Results 131 to 140 of about 1,852,356 (316)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
An exploration of demand for physical activity
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis is to contribute to the understanding of demand for physical activity.
Anokye, Nana Kwame
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Economic Choice of Participation and Time Spent in Physical Activity and Sport in Canada [PDF]
The health benefits of participation in physical activity are well documented, yet the prevalence of meeting physical activity guidelines remains low. We examine the determinants of participation in physical activity in Canada by estimating double hurdle
Humphreys, Brad, Ruseski, Jane
core
Towards the optimization of passive undulatory locomotion on land: mathematical and physical models. [PDF]
J R Soc Interface, 2023 Yaqoob B +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Breach parameters for cascade dams’ breaks using physical, empirical and numerical modeling
RBRHThe environmental, economic, and social consequences of dam breaks are catastrophic and require their prior knowledge to minimize risks. These consequences are directly related to rupture breach parameters, such as formation time and breach geometry ...
Rubens Gomes Dias Campos +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Understanding Passive Membrane Permeation of Peptides: Physical Models and Sampling Methods Compared. [PDF]
Int J Mol Sci, 2023 Mazzanti L, Ha-Duong T.
europepmc +1 more source