Results 81 to 90 of about 14,720,819 (304)

Musculoskeletal adaptations to strength training in frail elderly: a matter of quantity or quality?

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background The improvement in muscle strength generally exceeds the increase in muscle size following strength training in frail elderly, highlighting the complex aetiology of strength deficit in aging. The aim of this study was to investigate the effect
Sigve N. Aas, Markus Breit, Stian Karsrud, Ole J. Aase, Simen H. Rognlien, Kristoffer T. Cumming, Carlo Reggiani, Olivier Seynnes, Andrea P. Rossi, Luana Toniolo, Truls Raastad   +10 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A putative (private) life of Hannah Arendt. Bio-portraiture as performance in the work of Miriam Shenitzer [PDF]

, 2019
The paper uses tropes culled from several of Hannah Arendt's works, as well as Rebecca Schneider's performance-theoretical considerations on "reenactment", to analyze the work of artist Miriam Shenitzer, specifically a show of drawings, captions, and ...
Zank, Michael
core   +1 more source

Human gene for physical performance

Nature, 1998
A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An ‘insertion’ allele of the gene is associated with elite endurance performance among high-altitude mountaineers.
Montgomery, H, Marshall, R, Hemingway, H, Myerson, S, Clarkson, P, Dollery, C, Hayward, M, Holliman, D, Jubb, M, World, M, Thomas, E, Brynes, A, Saeed, N, Barnard, M, Bell, J, Prasad, K, Rayson, M, Talmud, P, Humphries, SE   +18 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Events and event records (scoring and penalties) across temporal units in elite judo contests: implications for tactical preparation

Revista de Artes Marciales Asiáticas
Introduction: This study examines the distribution of events and event records (EVRs) in elite judo competitions, encompassing both male and female categories.
Xurxo Dopico-Calvo, Luis Santos, Eduardo Carballeira, Xian Mayo, Bayram Ceylan, Jožef Simenko , Marta Sevilla-Sanchez, Eliseo Iglesias-Soler   +7 more
doaj   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effect of Low-Load and Low-Volume Squat Training Combined with Plyometrics During a Full Season on Physical Performance in Young Soccer Players

Sports
The aim of this study was to analyze the effects of a 24-week low-load, low-volume resistance training (RT) program combined with plyometric exercises on the physical performance of U-15 male soccer players.
Felipe Franco-Márquez, Carmen Serrano-Cañadillas, Juan Manuel Yáñez-García, Juan José González-Badillo, David Rodríguez-Rosell   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source