Results 51 to 60 of about 5,002,472 (315)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The physical and chemical properties of planet forming disks [PDF]

, 2019
VLT instruments and ALMA have revolutionized in the past five years our view and understanding of how disks turn into planetary systems. They provide exquisite insights into non-axisymmetric structures likely closely related to ongoing planet formation ...
Kamp, I.
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analysis of the Physical Properties of Trehalose-water-lithium Iodide Based on the Bond Strength Coordination Number Fluctuation Model [PDF]

, 2010
The temperature dependence of the viscosity of trehalose-water-lithium iodide system has been investigated by the mean of the Bond Strength Coordination Number Fluctuation (BSCNF) model.
Aniya, M. (Masaru), Ndeugueu, J. L. (Jean), Sahara, S. (Sahara)   +2 more
core  

Physical properties of fullerene-containing Galactic planetary nebulae [PDF]

, 2013
We searched the Spitzer Space Telescope data archive for Galactic planetary nebulae (PNe), which show the characteristic 17.4 and 18.9 µm features due to C60, also known as buckminsterfullerene. Out of 338 objects with Spitzer/Infrared Spectrograph data,
Acker, Acker, Allamandola, Bernard-Salas, Bernard-Salas, Boersma, Cahn, Cami, Clayton, Cordes, Dopita, Draine, Draine, E. Peeters, Evans, F. Kemper, Ferland, García-Hernández, García-Hernández, García-Hernández, Gielen, Grishko, Henry, Henry, Higdon, Hony, Houck, Hubeny, J. Bernard-Salas, J. Cami, Jiang, Karakas, Kemper, Kondratyeva, Kroto, Lodders, Lombaert, Markwardt, Masaaki Otsuka, Messenger, Micelotta, Morisset, Morisset, Murakami, Onaka, Otsuka, Otsuka, Patriarchi, Peeters, Peeters, Pereira, Pottasch, Pottasch, Preite-Martinez, Ricca, Roberts, Schutte, Scott, Scott, Sellgren, Sharpee, Sloan, Sloan, Speck, Srinivasan, Stanghellini, Storey, Tajitsu, Vassiliadis, Wang, Weidmann, Weidmann, Williams, Woods, Zhang, Zhang, Zhang, Zhukovska, Zijlstra   +78 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Physical properties and crystal chemistry of Ce2Ga12Pt

, 2012
Single crystals of the new ternary compound Ce2Ga12Pt were prepared by the self-flux technique. The crystal structure with the space group P4/nbm was established from single-crystal X-ray diffraction data and presents a derivative of the LaGa6Ni0.6 ...
Grin, Yuri, Krellner, Cornelius, Prots, Yuri, Sichevych, Olga, Steglich, Frank   +4 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source