Results 91 to 100 of about 5,133,590 (283)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cosmic particles with energies above 10^19 eV: a brief review of results
, 2013 Experimental results on ultra-high-energy cosmic rays are briefly reviewed and their interpretation is discussed. The results related to principal observables (arrival directions, energies and composition) of primary particles of extended air showers as ...
Troitsky, Sergey
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Explaining the Gender Wage Gap in STEM: Does Field Sex Composition Matter?
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2016 Using the National Science Foundation's SESTAT data, we examine the gender wage gap by race among those working in computer science, life sciences, physical sciences, and engineering.
Katherine Michelmore, Sharon Sassler
doaj +1 more source
Physical sciences: Thermodynamics, cryogenics, and vacuum technology: A compilation [PDF]
Technological developments which have potential application outside the aerospace community are reported. A variety of thermodynamic devices including heat pipes and cooling systems are described along with methods of handling cryogenic fluids.
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Nonextensive statistical mechanics: A brief review of its present status
, 2002 We briefly review the present status of nonextensive statistical mechanics. We focus on (i) the central equations of the formalism, (ii) the most recent applications in physics and other sciences, (iii) the {\it a priori} determination (from microscopic ...
Tsallis, Constantino
core +4 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source