Results 131 to 140 of about 870,490 (254)

Preliminary Study on Different Types of Solid Dispersion Excipients for Improving the Water Solubility and Physical Stability of Celecoxib. [PDF]

Pharmaceutics
Liu B, Rui S, Cai Y, Qian R, Feng S, Liu Z, Zhao Q.   +6 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Contrasting effects of phase-oriented antioxidant localization on oxidative resistance and physical stability of double emulsions. [PDF]

NPJ Sci Food
Jeon S, Jeong J, Sumnu G, Sahin S, Choi MJ, Lee J.   +5 more
europepmc   +1 more source

A review of recent strategies to improve the physical stability of phycocyanin. [PDF]

Curr Res Food Sci, 2022
Yuan B, Li Z, Shan H, Dashnyam B, Xu X, McClements DJ, Zhang B, Tan M, Wang Z, Cao C.   +9 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Impact of Water Activity on Physical Stability and Bioactive Compound Retention in Yellow Pitaya (<i>Selenicereus megalanthus</i>) Pulp Powder. [PDF]

Foods
Tormos A, Larrea V, Hernando I, Moraga G.   +3 more
europepmc   +1 more source

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

Exploring the Phytochemical and Physical Stability of Phycocyanin, Anthocyanins, and Betacyanin in a Cheesecake Product. [PDF]

Mol Nutr Food Res
Selin C, Tanislav A, Stan L, Teleky BE, Ciont Nagy C, Ranga F, Mureşan V, Mureşan A, Vodnar DC, Mihai M, Morariu ID, Pop OL.   +11 more
europepmc   +1 more source

In Vitro Optical and Physical Stability of Resin Composite Materials with Different Filler Characteristics. [PDF]

Polymers (Basel), 2023
Islam MS, Nassar M, Elsayed MA, Jameel DB, Ahmad TT, Rahman MM.   +5 more
europepmc   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source