Results 71 to 80 of about 6,894,347 (240)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Stimulation-induced artifact.

, 2023
(A) During the stimulation session, local field potentials were recorded from bipolar contacts surrounding the stimulation electrode. Despite common mode rejection, the artifact was clearly visible in the unprocessed data.
Muthuraman Muthuraman (328846), Rafal Bogacz (307953), Sergiu Groppa (3590291), Huiling Tan (500089), Peter Brown (209993), Manuel Bange (16007091), Alek Pogosyan (500091), Martin Glaser (1395892), Damian M. Herz (16007088), Gabriel Gonzalez-Escamilla (6286490), Miriam Auer (16007094)   +10 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation [PDF]

, 2013
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition.
Green, Alexander L, Zrinzo, L, Brittain, John-Stuart, Aziz, Tipu, Green, AL, Zrinzo, Ludvic, Little, S, Cagnan, H, Little, Simon, Limousin, P, Fitzgerald, James, Foltynie, Thomas, Hariz, Marwan, Brittain, JS, Limousin, Patricia, Aziz, T, Brown, Peter, Joint, Carole, Fitzgerald, J, Hariz, M, Cagnan, Hayriye, Foltynie, T, Brown, P, Joint, C   +23 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Practical Study: Physical Therapy and Iontophoresis

, 1999
vi, 40 p.Electrical stimulation plays a significant role in the field of physical therapy and rehabilitation. Many electrical stimulation mechanisms can be found in a typical rehabilitation clinic and there is a significant difference among the use and ...
Borlaza, Kristina A.
core   +1 more source

Effect of Thermal Stimulation on Corticomotor Excitability in Patients with Stroke

, 2017
Objective: This study examined the immediate effects of noxious and innocuous thermal stimulation intervention on corticomotor excitability for the paretic arm in patients with stroke.
Tai, I; Lai, Chiou-Lian; Hsu, Miao-Ju; Lin, Ruey-Tay; Huang, Mao-Hsiung; Lin, Chuan-Li; Hsieh, Ching-Lin; Lin, Jau-Hong
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Advances in neuromodulation for treatment of dystonia

Chinese Journal of Contemporary Neurology and Neurosurgery
Dystonia is a group of movement disorders characterized by continuous or intermittent muscle contraction, causing abnormal movements and/or repetitive postures. It has the characteristics of diverse causes and complex clinical symptoms.
LIANG Nan, MA Ling⁃yan, MENG Fan⁃gang, ZHANG Jian⁃guo   +3 more
doaj   +1 more source