Results 91 to 100 of about 9,367,004 (306)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Decreasing adhesions and avoiding further surgery in a pediatric patient involved in a severe pedestrian versus motor vehicle accident

Pediatric Reports, 2014
In this case study, we report the use of manual physical therapy in a pediatric patient experiencing complications from a life-threatening motor vehicle accident that necessitated 19 surgeries over the course of 12 months.
Amanda D. Rice, Leslie B. Wakefield, Kimberley Patterson, Evette D'Avy Reed, Belinda F. Wurn, C. Richard III King, Lawrence J. Wurn   +6 more
doaj   +1 more source

Communiqué [PDF]

, 2010
Quarterly newsletter issued by the Texas Board of Physical Therapy Examiners to provide updates from Board meetings, information about administrative procedures, and articles about current practice and other topics of interest to physical ...
Texas Board of Physical Therapy Examiners
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

We are Ready for 2024!

International Journal of Sports Physical Therapy, 2023
International Journal of Sports Physical Therapy
doaj   +1 more source

Using 30-s Prone Back Extension Repetition Maximum Test to Predict Concentric and Eccentric 1 Repetition Maximum Squat Strength in Young and Older Adults

Journal of Aging Research
Discussion: Novel data from our study show that 30-s prone back extension repetition maximum can predict 1RM of concentric and eccentric squat strength in young and older adults, respectively. Thus, clinicians and rehabilitation professionals can use our
Michael T. Dunn, Phuong Quach, Monica McGraw, Robert C. Barefoot, Richard I. Preus, Donald H. Lein, Harshvardhan Singh   +6 more
doaj   +1 more source

Doctor of Physical Therapy program

, 2016
See more information at the Department of Physical Therapy web pages: http://www.wichita.edu/thisis/home/?u=pt (Accessed April 25, 2016.
Department of Physical Therapy
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Physical Therapy Program accreditation

, 2016
An accreditation letter confirming continuing accreditation for the Physical Therapy program at Wichita State ...
American Physical Therapy Association. Commission on Accreditation in Physical Therapy Education
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source