Results 101 to 110 of about 9,367,004 (306)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Effect of body mass index on quadriceps angle and tibial torsion in school-aged children

Bulletin of Faculty of Physical Therapy
Background The prevalence of excessive body mass (BMI) is increasing in pediatric population. Accordingly, the number of musculoskeletal problems in this population is also likely to increase.
Hanaa Ahmed Elhoseny, Amira Mohamed Eltohamy, Olfat Abdelrahman Diab   +2 more
doaj   +1 more source

Communiqué [PDF]

, 2016
Quarterly newsletter issued by the Texas Board of Physical Therapy Examiners to provide updates from Board meetings, information about administrative procedures, and articles about current practice and other topics of interest to physical ...
Texas Board of Physical Therapy Examiners
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Communiqué [PDF]

, 2019
Quarterly newsletter issued by the Texas Board of Physical Therapy Examiners to provide updates from Board meetings, information about administrative procedures, and articles about current practice and other topics of interest to physical ...
Texas Board of Physical Therapy Examiners
core   +4 more sources

Movement smoothness and turning deficits during the timed up and go in older adults with chronic neck pain

Frontiers in Sports and Active Living
BackgroundThis study investigated phase-specific performance, movement smoothness, and turning kinematics during the Timed Up and Go (TUG) test in older adults with and without chronic neck pain (CNP).MethodsEighty-five older adults [CNP, n = 25; control
Thanya Madsalae, Tanapat Thongprong, Nithinun Chaikeeree, Rumpa Boonsinsukh   +3 more
doaj   +1 more source

Communiqué [PDF]

, 2013
Quarterly newsletter issued by the Texas Board of Physical Therapy Examiners to provide updates from Board meetings, information about administrative procedures, and articles about current practice and other topics of interest to physical ...
Texas Board of Physical Therapy Examiners
core  

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source