Results 81 to 90 of about 2,480,457 (299)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Abstracts for the 2023 International Symposium, Brussels, Belgium

International Journal of Sports Physical Therapy, 2023
Belgian Federation of Sports Physical Therapy, International Federation of Sports Physical Therapy   +1 more
doaj   +1 more source

Using 30-s Prone Back Extension Repetition Maximum Test to Predict Concentric and Eccentric 1 Repetition Maximum Squat Strength in Young and Older Adults

Journal of Aging Research
Discussion: Novel data from our study show that 30-s prone back extension repetition maximum can predict 1RM of concentric and eccentric squat strength in young and older adults, respectively. Thus, clinicians and rehabilitation professionals can use our
Michael T. Dunn, Phuong Quach, Monica McGraw, Robert C. Barefoot, Richard I. Preus, Donald H. Lein, Harshvardhan Singh   +6 more
doaj   +1 more source

Effectiveness of Mechanical Horse-Riding Simulators on Postural Balance in Neurological Rehabilitation: Systematic Review and Meta-Analysis [PDF]

, 2019
Mechanical horse-riding simulators consist of a device that mimics the movement of a real horse, generating between 50 and 100 three-dimensional physical movements (forward and back, left and right, up and down).
Assumpta Molina-Aroca, Bernstein, Carlos Luque-Moreno, Cho, Choi, David Lucena-Anton, De Miguel, Dominguez-Tellez, Jones, Jose A. Moral-Munoz, Juan G. Dominguez-Romero, Mancini, Saquetto   +12 more
core   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Expert Consensus on Key Writing Points for Inpatient Rehabilitation Treatment Documents

康复学报
Standardized rehabilitation treatment documents are of great significance to the clinical rehabilitation practice. At present, there is no "writing specification for rehabilitation treatment documents" available for reference, which substantially hinders
Chinese Physical Therapy Association, China Occupational Therapy Association   +1 more
doaj  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Radiation induced lichen planus - an uncommon side effect [PDF]

, 2019
Cutaneous lichen planus is classically characterized by violaceous, pruritic, planar papules and plaques, most commonly affecting the extremities. Lichen planus following radiation therapy is extremely rare and lichen planus following radiation therapy ...
Chen, Yi-Chun, Eastham, David V, Hadian, Yasmin, Schulman, Joshua M, Sood, Apra   +4 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source