Results 51 to 60 of about 165,108 (216)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Clinicians' and patients' assessment of activity overuse and underuse and its relation to physical capacity [PDF]

, 2012
To explore clinicians' and patients' (self)-assessment of activity overuse and underuse, and its relationship with physical capacity in patients with chronic musculoskeletal pain (CMP). Study design was cross-sectional.
de Jong, A.B., Preuper, H.R.S., Reneman, M.F., Reneman, M.F.; id_orcid   +3 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Effects of Person-Centered Physical Therapy on Fatigue-Related Variables in Persons With Rheumatoid Arthritis : A Randomized Controlled Trial

, 2016
OBJECTIVE: To examine effects of person-centered physical therapy on fatigue and related variables in persons with rheumatoid arthritis (RA).DESIGN: Randomized controlled trial.SETTING: Hospital outpatient rheumatology clinic.PARTICIPANTS: Persons with ...
Forsblad-d'Elia, Helena,, Mannerkorpi, Kaisa, Feldthusen, Caroline,, Feldthusen, Caroline, Mannerkorpi, Kaisa,, Dean, Elizabeth, Forsblad d'Elia, Helena,   +6 more
core   +1 more source

The prevalence of physical inactivity amongst Brazilian university students: its association with sociodemographic variables [PDF]

, 2009
Objective The prevalence of physical inactivity amongst adults has been increasing worldwide; however, few studies have been conducted on university freshmen.
Alex Pinheiro-Gordia, Santos-Silva, Diego A., Pinheiro-Gordia, Alex, Diego A. Santos-Silva, Bianchini de Quadros, Teresa M., Teresa M. Bianchini de Quadros, Petroski, Edio L., Edio L. Petroski   +7 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Physical activity and hemostatic and inflammatory variables in elderly men

, 2002
Background: Physical activity is associated with lower risk of cardiovascular disease, but the mechanisms are uncertain. Hemostatic and inflammatory markers have been linked with risk of cardiovascular disease.
Lowe, G.D.O., Rumley, A., Whincup, P.H., Lennon, L., Walker, M., Wannamethee, S.G.   +5 more
core  

Physical Activity and Adiposity Markers at Older Ages: Accelerometer Vs Questionnaire Data

, 2015
Physical activity is critically important for successful aging, but its effect on adiposity markers at older ages is unclear as much of the evidence comes from self-reported data on physical activity.
van Hees, Vincent ,, Singh-Manoux, Archana, Bell, Joshua, A, Bell, Joshua A., Elbaz, A, Cogranne, Pol, Sabia, Séverine, van Hees, VT, van Hees, Vincent T, Kivimaki, Mika, Bell, Joshua A, Cogranne, P, Kivimaki, M, van Hees, Vincent, T, Elbaz, Alexis, Singh-Manoux, A, Bell, JA, van Hees, Vincent T., Bell, Joshua ,, Sabia, S   +19 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source