Results 71 to 80 of about 165,108 (216)

Frailty and Physical Activity: Are all Physical Activity Variables Equal?

The Journals of Gerontology: Series A
Abstract Background Frailty, defined as diminished physiological and functional reserve, is linked to negative health outcomes such as falls, fractures, and disability. Physical activity dose plays a significant role in preventing and reducing physical frailty, but the influence of different PA ...
Wingood, Mariana, Jaeger, Byron C, Fanning, Jason, Callahan, Kathryn E   +3 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Abundance of the sponge Hymeniacidon cf. perlevis in a stressful environment of Patagonia: relationships with Ulva lactuca and physical variables [PDF]

, 2016
Understanding the variables (biotic or abiotic) controlling coastal communities is the main goal of ecology research and it is crucial to predict how communities will evolve under the increasing pressure on coastal systems by human activities.
Gastaldi, Marianela, Daleo, Pedro, Firstater, Fausto Nahuel, Narvarte, Maite Andrea   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Changes in leisure time and occupational physical activity over 8 years: The Cornellà health Interview Survey Follow-Up Study

, 2008
Aim: To describe changes in leisure time and occupational physical activity status in an urban Mediterranean population-based cohort, and to evaluate sociodemographic, health-related and lifestyle correlates of such changes.
Schiaffino, Anna, Cornelio, C. I., García, M., Borràs Andrés, Josep Maria, Nieto, F. Javier, Fernández Muñoz, Esteve   +5 more
core   +1 more source

Selection of Ordinally Scaled Independent Variables [PDF]

, 2009
Ordinal categorial variables are a common case in regression modeling. Although the case of ordinal response variables has been well investigated, less work has been done concerning ordinal predictors.
Gertheiss, Jan, Oberhauser, Cornelia, Hogger, Sara, Tutz, Gerhard   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Data Physicalization with Haptic Variables: Exploring Resistance and Friction

Extended Abstracts of the CHI Conference on Human Factors in Computing Systems
Data Physicalizations have the potential to create interactive and more engaging data experiences and to make data more accessible to a broader range of users than those reached by visualizations alone. Tapping into this potential necessitates an understanding of the strengths/weaknesses of the different encoding variables available to designers, and ...
Sander Dullaert, Champika Ranasinghe, Auriol Degbelo, Nacir Bouali   +3 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Economics of Participation and Time Spent in Physical Activity [PDF]

This paper examines the economics of participation in physical activity by developing a consumer choice model of participation and estimating it using data drawn from the Behavioral Risk Factor Surveillance Survey (BRFSS). Both emphasize that individuals
Humphreys, Brad, Ruseski, Jane
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