Results 51 to 60 of about 1,088,753 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gender, airborne chemical monitoring, and physical work environment are related to indoor air symptoms among nonindustrial workers in the Klang Valley, Malaysia

Therapeutics and Clinical Risk Management, 2013
Aizat Ismail Syazwan,1 Juahir Hafizan,2 Mohd Rafee Baharudin,1 Ahmad Zaid Fattah Azman,1 Zulkapri Izwyn,3 Ismail Zulfadhli,4 Katis Syahidatussyakirah11Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia ...
Syazwan AI, Hafizan J, Baharudin MR, Azman AZF, Izwyn Z, Zulfadhli I, Syahidatussyakirah K   +6 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Shift work and physical inactivity: findings from the Finnish Public Sector Study with objective working hour data

, 2020
Objectives Shift work is a risk factor for chronic diseases, and physical inactivity can have an influence on this association. We examined whether intra-individual changes in working time characteristics were associated with changes in physical ...
Ropponen, A,, Koskinen, A, Karhula, K, Oksanen, T, Härmä, M, Cheng, W-J   +5 more
core   +1 more source

Working environment, work engagement and mental health problems among occupational and physical therapists

Scandinavian Journal of Occupational Therapy, 2022
Background Working environment, work engagement and health among occupational and physical therapists in Norway have rarely been investigated. Objectives (1) To compare the psychosocial working environment, work engagement and mental health problems of ...
Steffen Torp, Linn Therese Jacobsen Bergheim   +1 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Physical Work Environment and its Relationship to Stress

, 2020
How we work and the environments in which we do it are changing rapidly. At the same time, workplace stress is rising, with high costs for individuals and organisations.
Caza, Arran, Jordan, Peter, Sander, Elizabeth J   +2 more
core  

Eating and shift work – effects on habits, metabolism and performance

, 2010
Compared to individuals who work during the day, shift workers are at higher risk of a range of metabolic disorders and diseases (eg, obesity, cardiovascular disease, peptic ulcers, gastrointestinal problems, failure to control blood sugar levels, and ...
Löwden, Arne,, Holmbäck, Ulf C.,, Moreno, Claudia Roberta,, Lennernäs, Maria,, Tucker, Philip T.,, Wiklund, Maria Lennernäs,, Moreno, C.R.C.,, Ulf Holmbäck, Philip Tucker, Arne Lowden, Claudia Moreno, Maria Lennernäs   +11 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source