Results 61 to 70 of about 1,088,753 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Psychological perceptions matter: Developing the reactions to the physical work environment scale

, 2019
There is clear research evidence that physical work environments (i.e., material spaces and objects) influence employee performance and wellbeing. As a result, these environments have received significant attention from both practitioners and researchers.
Caza, Arran, Elizabeth (Libby) J. Sander, Sander, Elizabeth, Jordan, Peter, Sander, Elizabeth Libby J, Peter J. Jordan, Arran Caza, Jordan, Peter J   +7 more
core   +1 more source

Uncovering the pattern of physical behaviours among Swedish ambulance personnel: is the type of work shift important?

BMC Public Health
Background Previous studies indicate that ambulance personnel have an increased risk of ill health. Shift work and time spent on physical behaviours during work and leisure are factors that could be related to health, however the research is limited ...
Anna M. Johnsen, Nidhi Gupta, Stavros Kyriakidis, Anders Broström, Petra Wagman, Eleonor I. Fransson   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Differences in call centre agents’ perception of their job characteristics, physical work environment and wellbeing [PDF]

Problems and Perspectives in Management, 2016
Orientation: job characteristics and physical work environment of call centres have an impact on the wellbeing of call centre agents. Research purpose: the aim of this study is to determine whether there are differences in male and female call centre ...
Noleen Miller, Rozenda Hendrickse
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Building health: an epidemiological study of "sick building syndrome" in the Whitehall II study

, 2006
Objectives: Sick building syndrome (SBS) is described as a group of symptoms attributed to the physical environment of specific buildings. Isolating particular environmental features responsible for the symptoms has proved difficult.
Stansfeld, S.A., Marmot, A.F., Warwick, E., Eley, J., Stafford, M., Marmot, M.G., A F Marmot   +6 more
core   +1 more source

Prediction of objectively measured physical activity and sedentariness among blue-collar workers using survey questionnaires [PDF]

, 2016
OBJECTIVES: We aimed at developing and evaluating statistical models predicting objectively measured occupational time spent sedentary or in physical activity from self-reported information available in large epidemiological studies and surveys.METHODS ...
Heiden, Marina, Holtermann, Andreas, Heiden, Marina,, Gupta, Nidhi,, Gupta, Nidhi, Mathiassen, Svend Erik, Holtermann, Andreas,, Mathiassen, Svend Erik,   +7 more
core   +1 more source