Results 61 to 70 of about 3,115 (303)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Realizer-functionalism and Life After Death [PDF]
پژوهشنامه فلسفه دین, 2019 In contemporary philosophy of mind, some have tried to reduce mental states to physical and bodily states by proposing a model that draws upon both functionalism and the identity theory; thus, reducing the human person to his/her physical body and ...
Mahdi Ghiasvand
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Frontiers in Systems Neuroscience, 2016 Is it possible to turn psychology into "hard science"? Physics of the mind follows the fundamental methodology of physics in all areas where physics have been developed. What is common among Newtonian mechanics, statistical physics, quantum physics, thermodynamics, theory of relativity, astrophysics… and a theory of superstrings?
openaire +3 more sources
Information, 2012 In this paper I discuss the question: what comes first, physics or information? The two have had a long-standing, symbiotic relationship for almost a hundred years out of which we have learnt a great deal. Information theory has enriched our interpretations of quantum physics, and, at the same time, offered us deep insights into general relativity ...
Vedral, V, Vedral, V
openaire +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The Irrationality of Physicalism [PDF]
, 2014 This paper argues, not that physicalism is wrong, but that it is irrational. The paper defines standards of rationality, both metaphysical and epistemological, that physicalism necessarily inherits from science.
Lewtas, Patrick Kuehner +2 more
core +1 more source