Results 71 to 80 of about 12,681 (313)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Revista de Filosofia, 2006 Physicalism claims that colors are physical properties of physical objects. For more than three centuries this philosophical stand has been denied because it was considered not to be “scientifically serious”. In this article we offer a critical review of
Andoni Ibarra, Ekai Txapartegi
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
How Philosophy of Mind Needs Philosophy of Chemistry [PDF]
, 2008 By the 1960s many (perhaps most) philosophers had adopted ‘physicalism’ ─ the view that physical causes fully account for mental activities. However, controversy persists about what count as ‘physical causes’.
Earley, Joseph
core +3 more sources
Frontiers in Human NeuroscienceThis article addresses the question of which metaphysical paradigm is most suitable for gaining a deeper understanding of our conscious inner life and bringing us closer to a powerful theory of consciousness (TOC).
Joachim Keppler
doaj +1 more source
Revisiting Galison’s ‘Aufbau/Bauhaus’ in light of Neurath’s philosophical projects [PDF]
, 2006 Historically, the Vienna Circle and the Dessau Bauhaus were related, with members of each group familiar with the ideas of the other. Peter Galison argues that their projects are related as well, through shared political views and methodological ...
Potochnik, Angela, Yap, Audrey
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Is Consciousness Intrinsic?: A Problem for the Integrated Information Theory [PDF]
, 2019 The Integrated Information Theory of consciousness (IIT) claims that consciousness is identical to maximal integrated information, or maximal Φ. One objection to IIT is based on what may be called the intrinsicality problem: consciousness is an intrinsic
Mørch, Hedda Hassel
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source