Results 71 to 80 of about 3,115 (303)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Revista de Filosofia, 2006 Physicalism claims that colors are physical properties of physical objects. For more than three centuries this philosophical stand has been denied because it was considered not to be “scientifically serious”. In this article we offer a critical review of
Andoni Ibarra, Ekai Txapartegi
doaj
EDULEARN Proceedings, 2019 Halfway between the experiment and the focus group, between the quiz and a game, we have experienced a new format to \"focus\" on sustainability and the fundamental laws of thermodynamics and its principles. Concepts as reversibility, efficiency and entropy, are then \"visualized\" by the participants, showing the relations with the economic value ...
Domenici, D., Mazzitelli, G.
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The Causal Argument for Physicalism
, 2008 Physicalism can be thought of as the view that the mental is “nothing over and above” the physical. I defend a formulation of this view based on supervenience.
Yates, David
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
THE ROLE OF CONSCIOUSNESS IN ELECTORAL BEHAVIOR: PHILOSOPHICAL ANALYSIS
Епістемологічні дослідження у філософії, соціальних і політичних наукахThe publication examines the problems of the philosophical foundations of elections, the concept of physicalism, where consciousness-body is studied, which in the philosophy of consciousness has a decisive fact.
Ірина Анатоліївна ФАРАФОНОВА
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source