Results 81 to 90 of about 3,115 (303)
, 2018 United States patent law’s view on the need for a physical embodiment of the invention, and the continued production and use of an embodiment, has varied over the last two centuries. In the early days, the requirement for “physicalism” was high, with the
Christopher A Cotropia
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Strong Emergence as a Defese of Non-Reductive Physicalism
Principia: An International Journal of Epistemology, 2002 Jaegwon Kim, and others, have recently posed a powerful challenge to both emergentism and nom-reductive physicalism by providing arguments that these positions are committed to an untenable combination of both ‘upward’ and ‘dounward’ determination.
Carl Gillett
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Lightweight and Heavyweight Anti-physicalism [PDF]
, 2022 I define two metaphysical positions that anti-physicalists can take in response to Jonathan Schaffer’s ground functionalism. Ground functionalism is a version of physicalism where explanatory gaps are everywhere.
Aleksiev, Damian
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Nancey Murphy's Nonreductive Physicalism
Zygon, 1999 This essay examines Nancey Murphy's commitment to downward causation and develops a critique of that notion based upon the distinction between the causal relevance of a higher‐level event and its causal efficacy.
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St Andrews Encyclopaedia of Theology, 2023 Historically and today, the movement of naturalism affirms the reality of the natural world, rejecting religious views of God, the soul, and values when these are understood to be supernatural or transcending the natural world.
Charles Taliaferro
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
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