Results 91 to 100 of about 5,654 (286)
Strong Emergence as a Defese of Non-Reductive Physicalism
Principia: An International Journal of Epistemology, 2002 Jaegwon Kim, and others, have recently posed a powerful challenge to both emergentism and nom-reductive physicalism by providing arguments that these positions are committed to an untenable combination of both ‘upward’ and ‘dounward’ determination.
Carl Gillett
doaj
THE ROLE OF CONSCIOUSNESS IN ELECTORAL BEHAVIOR: PHILOSOPHICAL ANALYSIS
Епістемологічні дослідження у філософії, соціальних і політичних наукахThe publication examines the problems of the philosophical foundations of elections, the concept of physicalism, where consciousness-body is studied, which in the philosophy of consciousness has a decisive fact.
Ірина Анатоліївна ФАРАФОНОВА
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Nancey Murphy's Nonreductive Physicalism
Zygon, 1999 This essay examines Nancey Murphy's commitment to downward causation and develops a critique of that notion based upon the distinction between the causal relevance of a higher‐level event and its causal efficacy.
doaj +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Non-Reductive Physicalism and the Limits of the Exclusion Principle [PDF]
, 2008 It is often argued that higher-level special-science properties cannot be causally efficacious since the lower-level physical properties on which they supervene are doing all the causal work.
Menzies, Peter, List, Christian
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source