Results 91 to 100 of about 5,433 (285)
Presentism, Passage, Phenomenology and Physicalism
ManuscritoTemporal dynamists argue that we should believe that there exists temporal passage because there being passage is the best explanation for the presence of our temporal phenomenology.
Kristie Miller, Jane Weiling Loo
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A Surprising Closeness in Latin American Academia: Luther and Certain Neurosciences
Open Theology, 2018 The purpose of this paper is to show a surprising coincidence between Lutheran Protestantism and physicalist neurosciences regarding the negation of free will and how this issue can begin to be studied in Latin American academia.
Martínez-Barrera Jorge
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The possibility of physicalism
Dementia & NeuropsychologiaModern science has undermined belief in countless imaginary causalities. What is the nature of the relation between mind and brain? Philosophers have debated the issue for millennia, but it is only in the last twenty years that empirical evidence has ...
Eduardo Giannetti
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A psique ao encontro da matéria: corpo e pessoa no projeto médico-científico de Nise da Silveira
História, Ciências, Saúde: ManguinhosResumo No início do século XX, a psiquiatria brasileira foi caracterizada por controversos métodos de tratamento, como a eletroconvulsoterapia, as psicocirurgias e o coma insulínico. Em 1946, a médica alagoana Nise da Silveira ocupou a linha de frente na
Felipe Sales Magaldi
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source