Results 91 to 100 of about 407,633 (303)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Doctoral education for physician assistants/associates: trends and characteristics in the U.S.

BMC Medical Education
Background PA-specific post professional doctoral programs have gained traction in the U.S. over the past decade, but little is known about their structure and outcomes.
Aurielle Eileen Rowe Martin, Gerald Kayingo   +1 more
doaj   +1 more source

Physician Faculty Scholars Program 2005-2012 [PDF]

, 2012
Describes the scope, goals, successes, challenges, and lessons of RWJF's career development program which supports physicians' academic careers with three-year research grants.

core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

2009 Alaska Health Workforce Vacancy Study [PDF]

, 2009
Alaska continues to experience health professional shortages. The state has long had a deficient “supply side” characterized by insufficient numbers of key health workers whose recruitment, retention, and training have been impeded by Alaska’s ...
DeRoche, Patricia, Doucette, Sanna, Frazier, Rosyland, Hill, Alexandra, Johnson, Kristin, Landon, Beth, Martin, Stephanie, Prator, Donna, Sanders, Kate, Sharp, Suzanne, Silver, Darla, Wilson, Meghan   +11 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Echocardiography curriculum development for physician assistants using entrustable professional activities [PDF]

, 2017
BACKGROUND: With the projected increase of cardiovascular disease in the aging population, a higher demand for echocardiography use is predicted. However, there is a shortage in the supply of cardiologists, to the point that a 2009 American College of ...
Moon, Saemyi
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1973
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1087/thumbnail ...

core   +4 more sources

Where to Live and Work? Examining the Influence Of job and Community Characteristics On Post-graduation Plans among Physician Assistant Students

Journal of Rural and Community Development, 2020
Physician assistants are one way to address the healthcare provider shortage in rural areas. However, recruitment and retention of physician assistants to live and work in rural communities remain a challenge.
Anjel Stough-Hunter, Kristi S Lekies
doaj