Results 41 to 50 of about 145,897 (292)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Aging Physician and Other Professionals

, 2017
Capacity to practice ones’ profession safely and effectively may become an issue as physicians or other professionals age. While this chapter will focus primarily on the psychiatric assessment of the aging physician, impairment due to illness in persons ...
Donald J. Meyer, Marilyn Price
core   +1 more source

Objective napping, cognitive decline, and risk of cognitive impairment in older men [PDF]

, 2019
IntroductionLittle is known about the longitudinal association between napping and cognitive impairment in older adults.MethodsWe used wrist actigraphy to measure naps in 2751 community-dwelling older men.
Kristine Yaffe, Katie L. Stone, Ancoli-Israel, Sonia, Sonia Ancoli‐Israel, Yaffe, Kristine, Susan Redline, Leng, Yue, Redline, Susan, Yue Leng, Stone, Katie L   +9 more
core   +1 more source

Prevalence, Risk Factors, and Impact of Undiagnosed Visually Significant Cataract: The Singapore Epidemiology of Eye Diseases Study. [PDF]

PLoS ONE, 2017
To determine the prevalence, risk factors, and impact of undiagnosed visually significant cataract in an Asian population.The Singapore Epidemiology of Eye Diseases is a population-based study where 8,697 adults of Malay, Indian, and Chinese ethnicities ...
Jacqueline Chua, Blanche Lim, Eva K Fenwick, Alfred Tau Liang Gan, Ava Grace Tan, Ecosse Lamoureux, Paul Mitchell, Jie Jin Wang, Tien Yin Wong, Ching-Yu Cheng   +9 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Screening older people for impaired vision [PDF]

A systematic review of trials about screening older people for visual impairment found no evidence that screening improved vision. We undertook a new trial nested within a larger cluster randomised trial of multidimensional ...
Smeeth, Liam
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Surgeons’ non-transparent facemasks challenge the physician–patient relationship in the orthopedic outpatient clinic of a tertiary university hospital during the COVID-19 pandemic: a prospective cohort study of 285 patients

Acta Orthopaedica, 2022
Background and purpose — Facemasks play a role in preventing the respiratory spread of SARS-CoV-2, but their impact on the physician–patient relationship in the orthopedic outpatient clinic is unclear.
Kristian Nikolaus Schneider, Christoph Theil, Georg Gosheger, Lukas Peter Lampe, Robert Rödl, Alexander Mellmann, Stefanie Kampmeier, Carolin Rickert   +7 more
doaj   +1 more source

Additional file 1: of How broad are state physician health program descriptions of physician impairment?

, 2018
Physician health program descriptions, weblinks, and additional context.
Nicholas Lawson (5681768), J. Boyd (4609186)   +1 more
core   +1 more source

Real-world work productivity is impaired in people with metabolic dysfunction-associated steatotic liver disease in the USA

JHEP Reports
Background & Aims: The impact of metabolic dysfunction-associated steatohepatitis (MASH) on patient-reported outcomes is poorly understood. We assessed work productivity burden in a real-world population with suspected/confirmed MASH, comparing work ...
Shraddha Shinde, Mary E. Rinella, Mark L. Hartman, David Schapiro, Victoria Higgins, Andrea Leith, James Pike, Quentin M. Anstee   +7 more
doaj   +1 more source