Results 121 to 130 of about 1,473,116 (296)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thai Physicians’ Perceptions of Sources of Information About New Drugs in Terms of Amounts of Information and Trustworthiness

Siriraj Medical Journal, 2009
Objective: To determine Thai physicians’ opinions of sources of information about new drugs regarding amounts of information and the trustworthiness of the sources. Methods: Questionnaires developed by the research team were sent to physicians working at each regional/general hospital (92 totals) of the Ministry of Public Health in Thailand asking them
Summana Moolasarn, Chalongchai Bootchan, Piya Polkraisorn, Rungnapa Kongwong   +3 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Continuing professional development improves patient care, patient safety and physician wellbeing: International CPD standards and the knowledge tsunami

Global Pediatrics
Medical knowledge is evolving rapidly and expanding exponentially. The lifespan of information is now only 70 days, and a deluge of knowledge is predicted, driven by advances in information technology, artificial intelligence, the availability of large ...
Hilary Hoey, Thelma Russell, Deirdre Donegan, Jennifer Noordman, Holly Hanlon, Lucia Prihodova, Ann O’ Shaughnessy   +6 more
doaj   +1 more source

MOESM3 of Physiciansâ utilization of microbiologic reports and determinants of their preference to order culture in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

, 2018
Additional file 3. The number and type of microbiologic reports available for infected patients followed in medical ward of TASH in 2014, Addis Ababa, Ethiopia.
Alemkere, Getachew, Gilagil, Getu, Gebrehiwot, Teklu, Tilahun, Zelalem, Mengist, Hylemariam   +4 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Missed opportunities for improving practice performance in adult immunizations: a meta-narrative review of the literature

BMC Family Practice, 2017
Background We sought to characterize how the term “missed opportunities” is reported in the literature in the context of immunization rates and to assess how missed opportunities can be operationalized.
Natalia Loskutova, Craig Smail, Brian Webster, Kemi Ajayi, Julie Wood, Jennifer Carroll   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Texas Osteopathic Medical Association (TOMA) Archives [PDF]

, 2003
Finding aid for Texas Osteopathic Medical Association (TOMA) ArchivesThe Texas Osteopathic Medical Association was organized on November 29, 1900 in Sherman, Texas under the name Texas Association for the Advancement of Osteopathy. David L.
Texas Osteopathic Medical Association (TOMA)
core  

Sickness absence in hospital physicians: 2 year follow up study on determinants [PDF]

, 2001
Objectives-To identify determinants of sickness absence in hospital physicians.Methods-The Poisson regression analyses of short (1-3 days) and long (>3 days) recorded spells of sickness absence relating to potential determinants of sickness absence were ...
K Räsänen, S Töyry, R Sutinen, Elovainio, M., Vahtera, J, Elovainio, M, M Elovainio, Firth-Cozens, J, Kivimaki, M, Rasanen, K, Toyry, S, J E Ferrie, J Firth-cozens, Sutinen, R, M Kivimäki, Ferrie, JE, J Vahtera, Kivimäki, M., Sutinen R.   +18 more
core   +1 more source