Results 111 to 120 of about 1,473,739 (314)

Disparities in the access and provision of mental health services as part of primary health care: a case study of Ga-South district in the Greater Accra region

Frontiers in Public Health
Mental illness can be as debilitating as physical ailments, yet many mental health patients lack access to quality mental health care in low- and middle-income countries.
Abena Boahemaa Adusei, Roberta Naa Barkey Ayiku, Kezia Akosua Naa Amerley Amarteyfio, Eugene Paa Kofi Bondzie, Nhyira Yaw Adjei-Banuah, Abdul-Basit Abdul-Samed, Tolib Mirzoev, Irene Akua Agyepong   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Measuring the Productivity of Physicians and Evaluating the Factors that Influence such Productivity in Taiwan [PDF]

This study intends to focus on the physicians, and to examine the input-output relationships between the medical resources used by these physicians and the quantity of medical services provided by them, in order to analyze the productivity and efficiency
Chun Liu
core  

PEER ASSESSMENT: AN INNOVATIVE TOOL FOR ASSESSMENT IN HIGHER EDUCATION

Pakistan Armed Forces Medical Journal, 2015
Objective: To determine the correlation between peer and instructor assessment. Study Design: Correlation study. Place and Duration of Study: College of Physicians and Surgeons Pakistan (CPSP), in department of Medical Education (DME) from ...
Maneeza Kishwar, Amina Ahmad, Siraj ul Haque Sheikh, Javeria Ilyas   +3 more
doaj  

Effects of food insecurity risk on infant feeding confidence and practices during the COVID-19 pandemic and its waves

International Breastfeeding Journal
Background The COVID-19 pandemic and its aftermath changed numerous social and economic environments. Food insecurity rates rose with potential negative ramifications for infant feeding methods. The relationship between food insecurity and infant feeding
Maha Hussain, Jessica Hyun, Elena Arduin, Margaret H. Kyle, Wanda Abreu, Tessa Scripps, Adrita Khan, Melissa Glassman, Melissa S. Stockwell, Lauren Walzer, Dani Dumitriu, Cristina R. Fernández   +11 more
doaj   +1 more source