Results 41 to 50 of about 586,745 (312)

Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle [PDF]

, 2007
The potent immunomodulatory, anti-inflammatory and procoagulant properties of the protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been previously found to be modulated by a supramolecular monomer-trimer ...
Ambrosone, Bairoch, Bornberg-Bauer, Bourhis, Cai, Caporale, Cheng, Coeytaux, Csizmók, Doszatányi, Dosztányi, Dunker, Dunker, Dyson, D’Ambrosio, Esposito, Ferron, Gaboriaud, Galzitskaya, Galzitskaya, Galzitskaya, Garbuzynskiy, Harris, Hirose, Ialenti, Kandala, Kyte, Li, Lin, Linding, Linding, Liu, Lupas, MacCallum, McDonald, Metafora, Metafora, Miele, Murzin, Obradovic, Obradovic, Ostrowski, Pan, Prilusky, Quevillon-Cheruel, Radivojac, Ragone, Romero, Romero, Rüping, Shimizu, Shimizu, Sickmeier, Stiuso, Stiuso, Tompa, Tufano, Uversky, Uversky, Vucetic, Ward, Weathers, Weathers, Wolf, Wootton, Wright, Yang   +66 more
core   +3 more sources

How proteins bind macrocycles [PDF]

, 2014
The potential utility of synthetic macrocycles (MCs) as drugs, particularly against low-druggability targets such as protein-protein interactions, has been widely discussed. There is little information, however, to guide the design of MCs for good target
Beglov, Dmitri, Chennamadhavuni, Spandan, Kozakov, Dima, Porco, John A., Vajda, Sandor, Villar, Elizabeth A., Whitty, Adrian   +6 more
core   +1 more source

Physicochemical and Pharmacokinetic Analysis of Anacardic Acid Derivatives [PDF]

ACS Omega, 2020
Anacardic acid (AA) and its derivatives are well-known for their therapeutic applications ranging from antitumor, antibacterial, antioxidant, anticancer, and so forth. However, their poor pharmacokinetic and safety properties create significant hurdles in the formulation of the final drug molecule. As a part of our endeavor to enhance the potential and
Fahmina Zafar, Anjali Gupta, Karthick Thangavel, Kavita Khatana, Ali Alhaji Sani, Anujit Ghosal, Poonam Tandon, Nahid Nishat   +7 more
openaire   +3 more sources

Pyroclasts of the first phases of the explosive-effusive PCCVC volcanic eruption: physicochemical analysis [PDF]

, 2015
The morphology, texture, grain size and other physicochemical characteristics of pyroclastic material from the first phases of the Puyehue-Cordon Caulle volcanic complex (PCCVC) eruption, (Southern Andes, Chile), can be associated to the model recently ...
Barone, Vicente, Botto, Lia, Canafoglia, María E., Gazzoli, Delia, González, María J., Rovere, Elizabeth, Schalamuk, Isidoro, Violante, Roberto   +7 more
core   +2 more sources

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer’s Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Molecules
GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer’s disease due to their involvement in the misfolding and accumulation of amyloid β (Aβ) and tau proteins, as well as inflammatory processes.
Izabella Góral, Tomasz Wichur, Emilia Sługocka, Justyna Godyń, Natalia Szałaj, Paula Zaręba, Monika Głuch-Lutwin, Barbara Mordyl, Dawid Panek, Anna Więckowska   +9 more
doaj   +1 more source

Structural systematic studies and conformational analyses of a 3x3 isomer grid of fluoro-N-(pyridyl)benzamides; physicochemical correlations, polymorphism and isomorphous relationships [PDF]

, 2012
The effect of fluorine and pyridine N atom substitution patterns on molecular structure and conformation is probed in a 3 3 isomer grid (Scheme 1) of fluoro-N-(pyridyl)benzamides (Fxx) (C12H9N2OF, x = para-/meta-/ortho-) to evaluate and correlate ...
Gallagher, John F., Mocilac, Pavle
core  

Assessing the freshwater quality of a large-scale mining watershed : the need for integrated approaches [PDF]

, 2019
Water quality assessments provide essential information for protecting aquatic habitats and stakeholders downstream of mining sites. Moreover, mining companies must comply with environmental quality standards and include public participation in water ...
Arroyo, Nilton Deza, Beeckman, Eveline, De Saeyer, Nancy, De Schamphelaere, Karel, Forio, Marie Anne Eurie, Goethals, Peter, Mercado Garcia, Daniel, Sanchez Peña, Marco, Van Buggenhoudt, Cécile, Van Butsel, Jana, Wyseure, Guido   +10 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Lactic Acid Bacteria and Yeast Inocula Modulate the Volatile Profile of Spanish-Style Green Table Olive Fermentations [PDF]

, 2019
In this work, Manzanilla Spanish-style green table olive fermentations were inoculated with Lactobacillus pentosus LPG1, Lactobacillus pentosus Lp13, Lactobacillus plantarum Lpl15, the yeast Wickerhanomyces anomalus Y12 and a mixed culture of all them.
Arroyo López, Francisco Noé, Benítez Cabello, Antonio, Garrido Fernández, Antonio, Jiménez Díaz, Rufino, Morales Gómez, María Lourdes, Rodríguez Gómez, Francisco   +5 more
core   +1 more source