Results 51 to 60 of about 5,246,145 (317)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Point And Line Disclinations In Models Of The Blue Phases [PDF]

, 1997
The model of the liquid crystalline blue phases proposed by Alfred Saupe in 1969 is examined in light of the recent, successful theoretical models for these phases.
Collings, Peter J.
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Physics Needs Philosophy / Philosophy Needs Physics [PDF]

Scientific American, 2018
Contrary to claims about the irrelevance of philosophy for science, I argue that philosophy has had, and still has, far more influence on physics than is commonly assumed. I maintain that the current anti-philosophical ideology has had damaging effects on the fertility of science.
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The viewpoint of the preposition over

Corela, 2014
The goal of this study is to define the semantics attached to the notional and “temporal” uses of the preposition over from a viewpoint based on the assumption that language bears some relation to the external world.
Emmanuelle Roussel
doaj   +1 more source

KELT-18b: Puffy Planet, Hot Host, Probably Perturbed [PDF]

, 2017
We report the discovery of KELT-18b, a transiting hot Jupiter in a 2.87-day orbit around the bright ( V = 10.1), hot, F4V star BD+60 1538 (TYC 3865-1173-1).
Baldrige, A., Baştürk, Ö., Beatty, T. G., Benni, P., Berlind, P., Bieryla, A., Calkins, M. L., Cohen, David H., Collins, K. A., Colón, K. D., Curtis, I. A., DePoy, D. L., Eastman, J. D., Esquerdo, G. A., Fukui, A., Fulton, B. J., Gaudi, B. S., Gregorio, J., Howard, A. W., Isaacson, H., Jensen, Eric L.N., Joner, M. D., Kempton, E. M.-R., Kielkopf, J. F., Labadie-Bartz, J., Latham, D. W., Lund, M. B., Manner, M., Marshall, J. L., McLeod, K. K., Melton, C., Narita, N., Oberst, T. E., Oelkers, R. J., Penev, K., Penny, M. T., Pepper, J., Pogge, R. W., Reed, P. A., Relles, H., Rodriguez, J. E., Scarpetta, G., Siverd, R. J., Stassun, K. G., Stephens, D. C., Stevens, D. J., Stockdale, C., Tan, T. G., Tirrell, B., Trueblood, M., Trueblood, P., Tsuguru, R., Visgaitis, T., Weiss, L. M., Zambelli, R., Zhao, Y. S., Zhou, G.   +56 more
core   +2 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source