Results 51 to 60 of about 2,276,450 (359)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Experience implementing curricular activities in physics to familiarize students with SDGs 5 and 7

Feminismo/s
This paper presents an experience of implementing curricular activities that aim to familiarise students with the Sustainable Development Goals (SDGs), thus promoting sustainability and the critical contextualisation of knowledge and highlighting the ...
Encina Calvo Iglesias
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Relationship between the cognitive load and the learning success in applying force diagrams: eye-tracking study

Frontiers in Education
IntroductionThis paper is concerned with investigating the cognitive demands of solving force diagram tasks in different scenarios, specifically in the wind context.MethodsIn this study, students were trained using worked examples and then completed ...
Yultuz Omarbakiyeva, Larissa Hahn, Pascal Klein, Ingrid Krumphals, Bianca Watzka, Bianca Watzka   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A Reply to John Dudley on Aristotle, Physics 2.5, 196b17–21

Peitho, 2017
In this article, I restate the interpretation of Aristotle’s Ph. 2.5, 196b17– 21, which I presented for the first time in my book I fondamenti della causalità naturale (2006).
Giovanna R. Giardina
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Improving Science Literacy Skills through Interactive Physics E-Learning for students at Lapandewa High School

JPPPF: Jurnal Penelitian & Pengembangan Pendidikan Fisika
This study aims to develop physics e-learning to improve students' science literacy skills at SMAN 3 Lapandewa. This research uses the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation).
Muslimin Boma, Rida Siti Nur'aini Mahmudah, Salam Salam, Ika Pratiwi, Syahrir Syahrir, Diki Chen, Nofianti Nofianti, Rezky Nur Ariatami   +7 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source