Results 71 to 80 of about 5,252,785 (363)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Constraints On Porosity And Mass Loss In O-Star Winds From The Modeling Of X-Ray Emission Line Profile Shapes [PDF]

, 2013
We fit X-ray emission line profiles in high resolution XMM-Newton and Chandra grating spectra of the early O supergiant zeta Pup with models that include the effects of porosity in the stellar wind.
Cohen, David H., Leutenegger, M. A., Owocki, S. P., Sundqvist, J. O.   +3 more
core   +1 more source

Physical objects, physical theories and what is physical in physicalism

Revista Dissertatio de Filosofia, 2017
Muitas tentativas malsucedidas de solucionar o problema de caracterizar o que é físico para o fisicalismo foram baseadas em um ou em outro aspecto de nosso conceito de físico, como a noção intuitiva de objeto físico ou a noção de físico como correspondendo ao domínio de investigação da física.
openaire   +3 more sources

Physics: The edge of physics [PDF]

Nature, 2009
Canada's Perimeter Institute of Theoretical Physics was intended to become a world leader in the field. Eric Hand finds out if it has lived up to its ambitions.
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Supercritical Conversion Of The 3rd Blue Phase To The Isotropic-Phase In A Highly Chiral Liquid-Crystal [PDF]

, 1995
The results of two independent experiments in the vicinity of the “transition” from the third blue phase ( BPIII) to isotropic phase ( I) are reported for a highly chiral liquid crystal.
Collings, Peter J., Garland, C. W., Kutnjak, Z., Passmore, J. Loren   +3 more
core   +2 more sources

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Improved Orbital Parameters And Transit Monitoring For HD 156846b [PDF]

, 2013
HD 156846b is a Jovian planet in a highly eccentric orbit (e = 0.85) with a period of 359.55 days. The pericenter passage at a distance of 0.16 AU is nearly aligned to our line of sight, offering an enhanced transit probability of 5.4% and a potentially ...
Ciardi, D. R., Dragomir, D., Fischer, D. A., Henry, G. W., Howard, A. W., Jensen, Eric L.N., Kane, S. R., Laughlin, G., Mahadevan, S., Pilyavsky, G., Ramirez, S. V., Von Braun, K., Wright, J. T.   +12 more
core   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

What do we expect, as teachers, when selecting a text for our students: comprehension or readability? [PDF]

Investigações em Ensino de Ciências, 1999
This paper analyzes the role that a group of college teachers of physics assigns to the comprehension of instructions and of concepts. Based on a text fragment, used to trigger answers, we discuss the "forms" that are attributed to the comprehension of ...
María Silvia Stipcich, Marta Massa
doaj