Results 21 to 30 of about 37,905 (263)

The Physics of Cosmic Acceleration [PDF]

Annual Review of Nuclear and Particle Science, 2009
The discovery that the cosmic expansion is accelerating has been followed by an intense theoretical and experimental response in physics and astronomy. The discovery implies that our most basic notions about how gravity works are violated on cosmological distance scales. A simple fix is to introduce a cosmological constant into the field equations for
Caldwell, Robert R., Kamionkowski, Marc
openaire   +3 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

A Survey of Interpretability of Machine Learning in Accelerator-based High Energy Physics

, 2020
Data intensive studies in the domain of accelerator-based High Energy Physics, HEP, have become increasingly more achievable due to the emergence of machine learning with high-performance computing and big data technologies.
Yuan, Bo, Lee Barnby, Ali Zahir, Danielle Turvill, Turvill, Danielle, Barnby, Lee, Zahir, Ali, Bo Yuan   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Major Accelerator Facilities for Nuclear Physics in Asia Pacific

, 2019
Asian Nuclear Physics Association (ANPhA) is the central organization representing nuclear physics in Asia Pacific. ANPhA is now preparing a list of accelerator facilities applicable for nuclear physics experiments in Asia Pacific.
Kazuhiro Tanaka, Tanaka, K
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Türk Hızlandırıcı Merkezi Infrared Serbest Elektron Lazer Laboratuarı için Kontrol Sistemi

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2010
Özet: Bu çalışmada, Türk Hızlandırıcı Merkezi (THM) infrared serbest elektron lazer (IR-SEL) laboratuarında kullanılması düşünülen EPICS (Experimental Physics and Industrial Control System) kontrol sistemi yazılımı tanıtılmıştır.
Emre Eroğlu, İlhan Tapan, Suat Özkorucuklu   +2 more
doaj  

European Strategy for Particle Physics -- Accelerator R&D Roadmap [PDF]

, 2022
The 2020 update of the European Strategy for Particle Physics emphasised the importance of an intensified and well-coordinated programme of accelerator R&D, supporting the design and delivery of future particle accelerators in a timely, affordable and ...
Lebrun, P., Previtali, E, Cross, A., Raubenheimer, T., Baudrenghien, P., Senatore, C., Williams, P., Burrows, P. N., Tanaka, O, Valente, A. -M., Seidel, M., Muggli, P, Jakobs, K, Lucchesi, D, Rochepault, E, Hooker, S, Bousson, S., Catalan-Lasheras, N., Shipman, N, Arnold, M., Nghiem, P., Rivkin, L., Neumann, A, Proslier, T., Pietralla, N., Militsyn, B, Grudiev, A, Baudrenghien, P, Musumeci, P, Marhauser, F, Losito, R., Shepherd, B., Yamamoto, Y., Muggli, P., Gerigk, F., Wenskat, M., Hooker, S., Koratzinos, M., Newbold, D., Burt, G, Marhauser, F., Brinkmann, R, Chancé, A., Chancé, A, Corner, L, Assmann, R, Arnold, Maurice, Arnold, M, Yokoya, K., Bossi, F., Stapnes, S., Rogers, C, Senatore, C, Gallo, A, García-Tabarés, L., Cenni, E., Hutton, A., Fazilleau, P., Nakada, T, Bentvelsen, S., Tennant, C., Lu, W., Corde, S, Bousson, S, Rosaz, G., Roser, T, Prestemon, S., Michizono, S., Vinokurov, N., Lamont, M, Osterhoff, J, Burrows, P.N., Latina, A, Bottura, L, Brunner, O., Long, K., Williams, P, Arndt, T., Rossi, L., Li, D., Kühn, J, Stratakis, D., Fazilleau, P, Yamamoto, A, Janot, P., Gilardoni, S, Leemans, W, Koratzinos, M, Longuevergne, D, Yokoya, K, Oide, K, Evtushenko, P, Brinkmann, R., Roser, T., Vaccarezza, C, Longuevergne, D., Cros, B, Ferrario, M, Syratchev, I, Rogers, C., Latina, A., Arndt, T, Zimmermann, F., Michizono, S, Lucchesi, D., Rimmer, B, Mounet, N, Nagaitsev, S., Previtali, E., Vieira, J, Yamamoto, Y, Seidel, M, Musumeci, P., Weise, H., Mnich, J., Ruber, R, Shepherd, B, Li, D, Corde, S., Nakada, T., Ballarino, A., Shipman, N., Specka, A., Hoffstaetter, G., Angal-Kalinin, D., Quettier, L, Gschwendtner, E., Brüning, O., Castilla, A., Adolphsen, C., Schulte, D., Montesinos, E, Wing, M, Delahaye, J.P., Bruker, M., Leemans, W., Lundh, O, Prestemon, S, Gianotti, F., Vaccarezza, C., Burt, G., Militsyn, B., Rimmer, B., Grudiev, A., Adolphsen, C, Benedikt, M., Stocchi, A., Bentvelsen, S, Gianotti, F, Raubenheimer, T, Baudouy, B, Tantawi, S, Evtushenko, P., Oide, K., Valente, A.-M., Védrine, P, Corner, L., Bogacz, A., Kayran, D, Devanz, G., Angal-Kalinin, D, Jensen, E, Cassou, K, Ballarino, A, Métral, E, Stocchi, A, Yamamoto, A., Benedikt, M, Ischebeck, R, Hoffstaetter, G, Gerigk, F, Long, K, Bruker, M, Knobloch, J, Rosaz, G, Zimmermann, F, Cross, A, Lundh, O., Losito, R, Vieira, J., Quettier, L., Noe, M, Kayran, D., Calatroni, S., Gallo, A., Calatroni, S, Jensen, E., Pastrone, N., Catalan-Lasheras, N, Auchmann, B., Palmer, M., Pietralla, N, Valente, A-M, Lebrun, P, Weise, H, Ischebeck, R., Ruber, R., Gschwendtner, E, Brüning, O, Vinokurov, N, Castilla, A, Hutton, A, Lu, W, Mnich, J, Faus-Golfe, A., Assmann, R., Védrine, P., Syratchev, I., Colino, N, Geddes, C, Pastrone, N, Blondel, A., Tanaka, O., Brunner, O, Newbold, D, Devanz, G, Hogan, M, Métral, E., Janot, P, Tsesmelis, E, Cros, B., Nagaitsev, S, Kaabi, W, Blondel, A, Colino, N., Noe, M., Kuske, B, Klein, M., Etienvre, A. -I., Rivkin, L, Neumann, A., Montesinos, E., Aulenbacher, K, Nghiem, P, Mounet, N., Specka, A, Burrows, PN, Tsesmelis, E., Baudouy, B., Cenni, E, Knobloch, J., Auchmann, B, Schulte, D, Gilardoni, S., Etienvre, A-I, Tennant, C, Wing, M., Stratakis, D, Rochepault, E., Delahaye, J. P., Shi, J, Faus-Golfe, A, Cassou, K., Bogacz, A, Shi, J., Etienvre, A.-I., Aulenbacher, K., Tantawi, S., Ferrario, M., Kühn, J., Proslier, T, Osterhoff, J., Palmer, M, Stapnes, S, García-Tabarés, L, Bottura, L., Lamont, M., Wenskat, M, Geddes, C., Hogan, M., Kaabi, W., Bossi, F, Rossi, L, Delahaye, JP, Klein, M, Jakobs, K., Kuske, B.   +276 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source