Results 21 to 30 of about 188,895 (243)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Physics opportunities with future proton accelerators at CERN [PDF]

, 2006
We analyze the physics opportunities that would be made possible by upgrades of CERN's proton accelerator complex. These include the new physics possible with luminosity or energy upgrades of the LHC, options for a possible future neutrino complex at ...
Blondel, A., Camilleri, L., Ceccucci, A., Ellis, J., Lindroos, M., Mangano, M., Rolandi, G.   +6 more
core   +1 more source

Underground Neutrino Detectors for Particle and Astroparticle Science: the Giant Liquid Argon Charge Imaging ExpeRiment (GLACIER)

, 2009
The current focus of the CERN program is the Large Hadron Collider (LHC), however, CERN is engaged in long baseline neutrino physics with the CNGS project and supports T2K as recognized CERN RE13, and for good reasons: a number of observed phenomena in ...
, , , , Acquafredda R . [OPERA Collaboration], Acquistapace G, Alciati M L, André Rubbia, Ankowski A [ICARUS Collaboration], Ardellier F, ArgoNeuT, Arneodo F [ICARUS Collaboration], Autiero D, Ayres D S [NOvA Collaboration], Badertscher A, Badertscher A, Badertscher A, Baldy R, Ball A E, Bandyopadhyay A [ISS Physics Working Group], Bechetoille E, Boccone V [The ArDM Collaboration], Bondar A, Bueno A, Bueno A, Bueno A, Bueno A, Bueno A, Bueno A, Bueno A, Campanelli M, Cennini P, Cline D B, Cocco A G, Eyssa, Fujii Y, Ge Y, Geer S, Gil I Botella, I Gil-Botella, Itow Y, Kodama K . [OPERA Collaboration], Komatsu M, Koshiba M, Kubota S, Meddahi M, Meregaglia A, Meregaglia A, MicroBOONE, Nath P, Nath P, Otiougova P, Pati J C, Pontecorvo B, Pontecorvo B, Pontecorvo B, Pontecorvo B, Pontecorvo B, Rubbia A, Rubbia A, Rubbia A, Rubbia A, Rubbia A, Rubbia A, Sakharov A D, Sakharov A D, Schwetz T, Shiozawa M [Super-Kamiokande Collaboration], Strauss T, Wiesenfeldt S, Yuanyuan Ge   +70 more
core   +1 more source

A Spectrometer to Study Elastic and Diffractive Physics at LHC [PDF]

, 1997
The possibility to study elastic and diffractive physics in pp collisions at LHC is investigated. For this purpose we have considered detectors close to the beam in conjunction with the magnetic elements of the accelerator to provide a high precision ...
Arneodo, M., Maselli, S., Peroni, C.
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Conversion of CESR to Operate as the Test Accelerator, CesrTA, Part 2: Vacuum Modifications

, 2015
Cornell's electron/positron storage ring (CESR) was modified over a series of accelerator shutdowns beginning in May 2008, which substantially improves its capability for research and development for particle accelerators.
Billing, M. G., Li, Y.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Jet Physics at the Tevatron

, 2010
Jets have been used to verify the theory of quantum chromodynamics (QCD), measure the structure of the proton and to search for the physics beyond the Standard Model. In this article, we review the current status of jet physics at the Tevatron, a sqrt(s)
Bhatti, Anwar, Lincoln, Don
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Türk Hızlandırıcı Merkezi Infrared Serbest Elektron Lazer Laboratuarı için Kontrol Sistemi

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2010
Özet: Bu çalışmada, Türk Hızlandırıcı Merkezi (THM) infrared serbest elektron lazer (IR-SEL) laboratuarında kullanılması düşünülen EPICS (Experimental Physics and Industrial Control System) kontrol sistemi yazılımı tanıtılmıştır.
Emre Eroğlu, İlhan Tapan, Suat Özkorucuklu   +2 more
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