Results 31 to 40 of about 1,914,502 (194)

Development of quantum perspectives in modern physics [PDF]

, 2009
Introductory undergraduate courses in classical physics stress a perspective that can be characterized as realist; from this perspective, all physical properties of a classical system can be simultaneously specified and thus determined at all future ...
Charles Baily, Baily, Charles, Finkelstein, Noah D., Noah D. Finkelstein   +3 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Physics Potential of a Long Baseline Neutrino Oscillation Experiment Using J-PARC Neutrino Beam and Hyper-Kamiokande [PDF]

, 2015
39 pages, 26 figures, submitted to PTEPHyper-Kamiokande will be a next generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande.
Detwiler, J, Minakata, H, Rayner, M. A., Tomura, T, Learned, JG, Redij, A., Tsukamoto, T, Uchida Y, Owen RA, Magaletti L, De Rosa, G., Rountree SD, Ludovici, L, Thompson, LF, Fernandez, P., Berardi, V., Monroe J, Detwiler, J., Ishitsuka M, Ravonel M, Kim, JY, Kajita, T., Kropp, W. R., Palomino JL, Radicioni, E., Kormos LL, Needham, M, Radicioni E, Perkin, J. D., Thompson, L. F., Sakuda, M., Ereditato, A, Vagins MR, Kishimoto, Y, Insler J, Quinto, M, Back JJ, Sanchez, M. C., Yamamoto, K, Thorpe, M, Riccio, C., Noah E, Bronner, C, Ikeda, M., Hadley, DR, Cowan G, Wilson JR, Smy, MB, Boyd SB, Abe K, Rose, HJ, Palladino, V., Barr, G., Ariga, T, Malek, M, Sinnis, G., et al., Carminati, G, Itow Y, Collazuol, G., Haga, Y, Ichikawa AK, Ma W, O'Sullivan, E., Palladino, V, Sinnis, G, Mori T, Longhin A, Di Luise S, Perez J, Palomino, JL, Mariani, C, Scholberg K, Xin, T, Short, S, Riccio, Ciro, Martin C, Intonti RA, Cremonesi, L, Owen, R. A., Payne D, Nakahata, M., Nowak, J., Tomura T, Lodovico, F. Di, Miura, M., Joo KK, Drapier, O., Himmel, A, Seiya Y, Collazuol, G, Karadhzov, Y., Inoue, K, Tomura, T., Pistillo, C, Ludovici L, Ganezer, K, Cafagna, F. S., Oyama, Y, Huang, K., Hierholzer, M, Minamino, A., Suda, Y., Scantamburlo, E, Owen, RA, Labarga, L, Ichikawa, AK, Asfandiyarov R, Seiya, Y., Haesler, A, Scott, M, Anghel I, Jamieson, B, Poutissou JM, Kim, SB, Barr, G, Jamieson, B., Yokoyama M, Ariga, A, Nakaya, T, Vasseur, G, Konaka, A, Shiozawa, M., Korzenev, A, Bolognesi, S, Fujii, Y., Stewart, T, Okumura K, Catanesi, M. G., Carminati, G., Feusels, T., Miura, M, Fukuda, D., O'Sullivan, E., Cartwright, S. L., Beltrame, P, Luise, SD, Anghel, I., Touramanis C, Horiuchi, S, Feusels T, Haesler, A., Pistillo C, Lim, IT, Koshio, Y., Tzanov, M, Drapier, O, Lindner T, Muheim F, Learned, J. G., COLLAZUOL, GIANMARIA, Galymov, V., Muheim, F., Okajima, Y., Ishida T, Lawe M, Shaikhiev A, McFarland, KS, Moriyama, S., Mueller, T, Yano T, Perevozchikov O, Zito, M, Intonti, R. A., Laveder, M., Terri, R., Magaletti, L., O'Keeffe, H. M., Detwiler J, Kaboth, A., Mezzetto, M., Itow, Y., Choi K, Martins, PPJ, Terri, R, Feusels, T, Di Lodovico F, Anghel, I, Bolognesi S, Svoboda R, Ishino H, Fitton M, Touramanis, Christos, Finch A, Perez, J., Mahn, K, Quilain, B, Hierholzer, Martin, Ishida, T., Richard, E., Bhadra S, Wilking, M. J., Itow, Y, Vogelaar, RB, Jung, C. K., Tobayama, S, Blaszczyk, F. D M, Yano, T, Ma, W., Pac MY, Hartfiel B, Bhadra, S, Nirkko, M., Jiang, M, Stone, JL, Paolone, V, Haga, Y., Paolone, V., Wendell, R., MAGALETTI, Lorenzo, Insler, J, Beltrame P, Mineev, O., Yanagisawa C, Tanaka HA, Rayner MA, Catanesi MG, Asfandiyarov, R., Nirkko M, Barker, GJ, Korzenev, A., Muheim, F, Kearns, E., Davies, G, Sacco, R., Posiadala-Zezula, M, Rayner, MA, Sekiguchi, T., Cartwright, SL, McGrew, C, Bay F, Thorpe, M., Barbi M, Tanaka, H, Berkman S, Sakuda, M, Lindner, T., Berardi, V, McGrew C, Posiadala Zezula, M., Di Lodovico, F, Jung, CK, Kameda, J, Mine S, Rubbia, A., Mineev, O, Drapier O, Joo, K. K., Pac, MY, Minakata H, Hill J, Kutter T, Wendell R, Tolich, N., Mine, S, Poutissou, J-M, Shiozawa M, Dewhurst, D., Ikeda M, Suda Y, Hierholzer, M., O'Sullivan E, Martins PPJ, Kearns, E, Martin, J. F., Hierholzer M, Scott M, Jiang M, Koshio Y, Kajita, T, Playfer, S., Mariani C, Ishida, T, Ichikawa, A. K., Karadhzov, Y, Nirkko, Martti, Marti L, Galymov, V, Okajima Y, Riccio, C, Tobayama, S., Vagins, M. R., Martins, P. P. J., Rondio, E., Lim, I. T., Yen, S., Ganezer K, Yen, S, Blaszczyk FdM, Nakamura, K, Takeuchi, Y, Weber, A., Poutissou, J. -M., Poutissou, J. M., Rountree, S. D., Pérez, J, Sanchez MC, Fernandez P, Kudenko Y, Nishimura, Y, Mine, S., Cowan, G, Thompson LF, Mori, T., Rubbia, André, Nicholls, T, Davies G, Mueller T, Tacik, R, Korzenev A, Kishimoto, Y., Catanesi, MG, Ikeda, M, Mcfarland, K. S., Sobel HW, Cafagna FS, Suzuki, Y., Scholberg, K, Haegel, L, Yen S, Oser, SM, Choi, J. H., Posiadala-Zezula M, Askins, M., Richard E, Walter, C. W., Hill, J., Martins, P. P J, Askins, M, Kropp WR, Proto-Collaborati, H-K, Tolich, N, Martin, C, Rosa, G. De, Pistillo, Ciro, Perkin JD, Kaboth A, Perevozchikov, O, Yanagisawa, C, Ballett, P., Noah, E, Suzuki, Y, Berardi V, Blondel, A, Ishino, H, Okajima, Y, Koga, M., Wilson, JR, Ratoff, PN, Lindner, T, Emery, S, Marti, L., Scott, M., Rubbia A, Sakuda M, Xin, T., O'Keeffe, HM, Martin JF, Galymov V, Khotjantsev, A, Khabibullin, M, Nirkko, M, Nakayama, S., Yokoyama, M., Lawe, M, Dewhurst D, Hayato Y, Smy MB, Ariga, Akitaka, Playfer S, Friend, M, Hartz, M., Karadhzov Y, Kobayashi, T, Mccauley, N., Nakahata, M, Bergevin, M., Choi, K., Aihara, H., Choi, JH, Hartz M, Tanaka, H. A., Yokoyama, M, Tacik R, Lagoda J, Wark D, Kudenko, Y., Sobel, H. W., Nunokawa, H, Mariani, C., Rubbia, A, Haesler A, Aihara, H, Proto-Collaboraion, Hyper-Kamiokande, Zito M, Sobczyk, J., Lagoda, J., Dewhurst, D, Beltrame, P., Rondio E, Densham C, Nakayama, S, Koga M, Andreopoulos, Constantinos, Sobczyk J, Densham, C, Wilking, MJ, Oyama, Y., Kormos, L. L., Friend M, Wilking MJ, Bolognesi, S., Shiozawa, M, Malek M, Fujii, Y, Yanagisawa, C., Shimizu, I., Hyper-Kamiokande Proto-Collaboration, Payne, David, Labarga, L., Kudenko, Y, Taketa, A., Sanchez, MC, Wilkes, RJ, Izmaylov A, Rountree, SD, Touramanis, C., Suzuki, AT, Kropp, WR, Kishimoto Y, Suzuki AT, Kim SB, Minamino, A, Tzanov, M., Stone, J. L., Svoboda, R., Nakamura K, Khotjantsev, A., Abe, K., Cremonesi L, DE ROSA, GIANFRANCA, Tanaka, H. K M, Tanaka, H., Sekiguchi, T, Scantamburlo, E., Mezzetto, M, Rose, H. J., Lagoda, J, Rott C, Sobel, HW, Tanaka, HA, Aihara H, Shaikhiev, A, Tsukamoto T, Sinnis G, Katori T, Longhin, A., Nicholls, T., Bravar A, Fitton, M, Moriyama S, Mazzucato, E, Barbi, M, Smy, M. B., Rose HJ, Ross-Lonergan M, Huang, K, Himmel A, Nowak, J, Ballett P, LAVEDER, MARCO, Kuze, M, Ludovici, L., Back, JJ, Boyd, SB, Hirota, S., Stewart, T., Jang, HI, Sacco, R, Taketa A, Mineev O, Bay, Francesca, Barker, G. J., McFarland KS, O'Sullivan, E, Mezzetto M, Perkin, JD, Kobayashi, T., Martin, JF, Labarga L, McCauley N, PALLADINO, VITTORIO, Bay, F, Mueller, T., Quinto M, Irvine, T., Emery, S., Blaszczyk, FDM, Mazzucato E, Berry, T, Hill, J, Zito, M., Nicholls T, Okumura, K, Touramanis, C, Khabibullin M, Tobayama S, Moriyama, S, Ereditato, Antonio, Lawe, M., Nunokawa, H., Bhadra, S., Berkman, S, Gonin, M., Scholberg, K., Ishino, H., Tacik, R., Yershov, N, Irvine, T, Seiya, Y, Vasseur G, Rondio, E, Wascko MO, Carminati G, Barr G, Stewart T, Poutissou, JM, Takeuchi, Y., Yershov, N., Xin T, Mcgrew, C., Fukuda D, Suda, Y, Ishitsuka, M, Rott, C., Wilkes RJ, Tanaka, H. K. M., Kobayashi T, Playfer, S, Barker GJ, Blondel, A., Hartz, M, Koga, M, Fukuda Y, Luise, S. Di, Izmaylov, A, Kim JY, Fujii Y, Gonin, M, Okumura, K., Learned JG, Ariga, T., Finch, A., Wilson, J. R., Ross-Lonergan, M, Jamieson B, Nishimura, Y., Cafagna, FS, Askins M, Uchida, Y, Haegel L, Shimizu I, Jung CK, Nakayama S, O'Keeffe, H. M., Imber, J., Radicioni, E, Wascko, M. O., Hirota S, Palladino V, Sekiya H, Takeda, A., Labarga Echeverría, Luis Alfonso, Tanaka, HKM, Boyd, S. B., Wark, D, Barbi, M., Magaletti, L, Nakamura, K., Kormos, LL, Densham, C., Kameda J, Andreopoulos, C., Wilkes, R. J., McCauley, N, Paolone V, Bronner, C., Shimizu, I, Yershov N, Oser SM, Scantamburlo E, Kim, J. Y., Di Luise, S, Inoue K, Ariga T, Quilain B, Vagins, MR, Ross Lonergan, M., Collazuol G, Ereditato, A., Martin, C., Gumplinger P, De Rosa G, Perevozchikov, O., Payne, D., Redij, Asmita Ajit, Ariga A, Terri R, Minamino A, Ravonel, M., Joo, KK, Takeda, A, Riccio C, Ravonel, M, Di Luise, Silvestro, Mori, T, Oser, S. M., Hirota, S, Wascko, MO, Longhin, A, Quinto, M., Walter CW, Monroe, J, Katori, T., Uchida, Y., Malek, M., Imber, J, Davies, G., Taketa, A, Di Luise, S., Fukuda, D, Berkman, S., Blondel A, Rosa, GD, Tanaka H, Konaka A, Takeuchi Y, Bravar, A., Fitton, M., Hartfiel, B., Tsukamoto, T., Hadley, D. R., Andreopoulos C, Ratoff, P. N., O'Keeffe HM, Koshio, Y, Retiere, F, Khabibullin, M., Nakahata M, Nunokawa H, Suzuki Y, Posiadala-Zezula, M., Needham M, Nakaya T, Palomino, J. L., Kutter, T., Fukuda, Y, Payne, D, Konaka, A., Tanaka HKM, Lodovico, FD, Kim, S. B., Yamamoto, K., Finch, A, Hayato, Y., Proto-Collaboraion, FTHK, Monroe, J., Abe, K, Vogelaar RB, Weber A, Horiuchi, S., Irvine T, Retiere, F., Cartwright SL, Gonin M, Minakata, H., Fukuda, Y., Ereditato A, Svoboda, R, Kajita T, Emery S, Izmaylov, A., Bergevin, M, Sobczyk, J, Noah, E., Stone JL, Imber J, Jang, H. I., Quilain, B., Sacco R, Intonti, RA, Redij, A, Cowan, G., Hadley DR, McCauley, Neil, Richard, E, Andreopoulos, C, Cremonesi, L., Di Lodovico, F., Redij A, Pac, M. Y., Wark, D., Jiang, M., Tzanov M, Ma, W, Iijima T, Miura M, Vogelaar, R. B., Haga Y, Ovsiannikova T, Ovsiannikova, T., Rott, C, Ratoff PN, BERARDI, Vincenzo, Haegel, L., Vasseur, G., Marti, L, Sekiguchi T, Tolich N, Yano, T., Ganezer, K., Laveder, M, Himmel, A., Katori, T, Walter, CW, Retiere F, Back, J. J., Lim IT, Short, S., Shaikhiev, A., Ovsiannikova, T, Jang HI, Berry, T., Kuze M, Bay, F., Mahn K, Huang K, Kaboth, A, Khotjantsev A, Nishimura Y, Kameda, J., Weber, A, Pistillo, C., Thorpe M, Ballett, P, Suzuki, A. T., Kearns E, Berry T, Wendell, R, Iijima, T, Ishitsuka, M., Yamamoto K, Mazzucato, E., Kuze, M., Hayato, Y, Laveder M, Kutter, T, Hartfiel, B, Sekiya, H, Iijima, T., Friend, M., Bronner C, Fernández, P, Nowak J, Ariga, A., Needham, M., Asfandiyarov, R, De Rosa, G, Choi JH, Gumplinger, P., Choi, K, Mahn, K., Short S, Ross-Lonergan, M., Ariga, Tomoko, Nakaya, T., Inoue, K., Sekiya, H., Horiuchi S, Oyama Y, Insler, J., Takeda A, Bravar, A, Blaszczyk, F. d. M., Bergevin M, Gumplinger, P   +785 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Report and recommendations on multimedia materials for teaching and learning quantum physics [PDF]

, 2015
An international collaboration of physicists, affiliated with Multimedia Physics for Teaching and Learning (MPTL) and MERLOT, performed a survey and review of multimedia-based learning materials for quantum physics and quantum mechanics.
Mason, B, Silva, J, Santi, L, Kohnle, A, Melder, T, Girwidz, R, Dębowska, E, Arpornthip, T, Greczyło, T, Michelini, M   +9 more
core   +1 more source