Results 31 to 40 of about 37,905 (263)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Accelerator physics at LEP [PDF]

Reports on Progress in Physics, 2000
Accelerator physics issues and their influence on performance are presented for the Large Electron-Positron (LEP) storage ring at CERN in Geneva, Switzerland. After several years of operation on the Z boson resonance at beam energies around 45 GeV, the beam energy was increased in steps to over 100 GeV. The major power loss to synchrotron radiation and
D Brandt, H Burkhardt, M Lamont, S Myers, J Wenninger   +4 more
openaire   +1 more source

An ultrashort pulse ultra-violet radiation undulator source driven by a laser plasma wakefield accelerator [PDF]

, 2014
Narrow band undulator radiation tuneable over the wavelength range of 150–260 nm has been produced by short electron bunches from a 2 mm long laser plasma wakefield accelerator based on a 20 TW femtosecond laser system.
Welsh, G. H., Shanks, R. P., de Loos, M.J., Jaroszynski, D.A., M. P. Anania, Brunetti, Enrico, Grant, D.W., Wiggins, Mark, Jaroszynski, D. A., Welsh, G.H., S. M. Wiggins, Cipiccia, S., Poole, M.W., Issac, R. C., M. W. Poole, Shanks, Richard, de Loos MJ, A. M. MacLeod, Clarke, J. A., R. C. Issac, R. P. Shanks, MacLeod, A.M., B. J. A. Shepherd, Welsh GH, Wiggins, S. M., Issac, Riju, Issac, R.C., Wiggins SM, Gillespie, W.A., Jaroszynski DA, D. A. Jaroszynski, Manahan, G. G., Anania MP, Cipiccia, Silvia, Cipiccia S, Poole MW, Clarke JA, C. Aniculaesei, Manahan, Grace, Grant, David William, Issac RC, Poole, M. W., G. G. Manahan, Manahan, G.G., Anania, M.P., Gillespie WA, van der Geer SB, Clarke, J.A., M. J. de Loos, Anania, Maria Pia, D. W. Grant, MacLeod AM, Grant, D. W., Shanks RP, Aniculaesei, Constantin, Brunetti E, van der Geer, S.B., Anania, M. P., S. Cipiccia, MacLeod, A. M., G. H. Welsh, W. A. Gillespie, Shepherd, B. J. A., van der Geer, S. B., Welsh, Gregor H., Aniculaesei, C., de Loos, M. J., Grant DW, Gillespie, W. A., Aniculaesei C, Jaroszynski, Dino, Manahan GG, E. Brunetti, J. A. Clarke, Shepherd, B.J.A., Shepherd BJA, Shanks, R.P., Brunetti, E., Wiggins, S.M., S. B. van der Geer   +79 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Computational Accelerator Physics Working Group Summary [PDF]

, 2004
The working group on computational accelerator physics at the 11th Advanced Accelerator Concepts Workshop held a series of meetings during the Workshop. Verification, i.e., showing that a computational application correctly solves the assumed model, and ...
Cary, John R., Bohn, Courtlandt L.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source