Results 21 to 30 of about 903,853 (126)
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Metan Molekülünün Elektron Etkisiyle İyonlaşma Dinamiğinin Çakışma Tekniği ile İncelenmesi
Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2014 Özet: Karmaşık moleküllerin elektronlarla etkileşimlerinin ayrıntılı bir biçimde anlaşılmasının atom ve molekül fiziği araştırmalarında, kuramsal modellemelerin gelişmesinde önemli bir yeri vardır. Özellikle moleküllerin dinamik yapılarının anlaşılmasına
Nimet IŞIK +2 more
doaj
FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Is Physics Sick? [In Praise of Classical Physics] [PDF]
arXiv, 2012 In this paper, it is argued that theoretical physics is more akin to an organism than to a rigid structure.It is in this sense that the epithet, "sick", applies to it. It is argued that classical physics is a model of a healthy science, and the degree of sickness of modern physics is measured accordingly.
arxiv
Modern Mathematical Physics: what it should be? [PDF]
arXiv, 2000 Personal view of author on goals and content of Mathematical Physics.
arxiv
Methods for Analyzing Pathways through a Physics Major [PDF]
, 2016 Physics Education Research frequently investigates what students studying physics do on small time scales (e.g. single courses, observations within single courses), or post-education time scales (e.g., what jobs do physics majors get?) but there is little research into how students get from the beginning to the end of a physics degree.
arxiv +1 more source
Fundamental Dilemmas in Theoretical Physics [PDF]
arXiv, 2014 In this paper, we argue that there are foundational dilemmas in theoretical physics related to the concept of reality and the nature of mathematics in physics. Physical theory is treated as a conceptual organism which develops under the weight of its internal contradictions.
arxiv