Results 11 to 20 of about 930,474 (234)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Les Houches 2015: Physics at TeV colliders - new physics working group report [PDF]

, 2016
We present the activities of the 'New Physics' working group for the 'Physics at TeV Colliders' workshop (Les Houches, France, 1-19 June, 2015). Our report includes new physics studies connected with the Higgs boson and its properties, direct search ...
Barducci, D., Bernon, J., Bharucha, A., Brehmer, J., Brivio, I., Brooijmans, G., Buckley, A., Burns, D., Cacciapaglia, G., Cai, H., Carmona, A., Carvalho, A., Chalons, G., Chen, Y., Chivukula, R. S., Conte, E., De Filippis, N., Deandrea, A., Delaunay, C., Delgado, A., Desai, N., Englert, C., Falkowski, A., Flacke, T., Frigerio, M., Fuks, B., Garcia-Pepin, M., Gleyzer, S., Goertz, F., Goudelis, A., Gras, P., Henrot-Versillé, S., Hewett, J. L., Ittisamai, P., Katz, A., Kopp, J., Kraml, S., Krauss, M. E., Kulkarni, S., Laa, U., Lacroix, S., Lane, K., Majumder, D., Martin, A., Mawatari, K., Mimasu, K., Mohan, K., Morse, D. M., Mühlleitner, M., Nardecchia, M., Nikitenko, S., No, J. M., Orlando, R. D., Pani, P., Papucci, M., Polesello, G., Pollard, C., Porod, W., Prosper, H. B., Quirós, M., Rizzo, T., Sakurai, K., Santiago, J., Sanz, V., Schmeier, D., Schmidt, T., Sekmen, S., Sengupta, D., Shao, H. -S., Simmons, E. H., Sonneveld, J., Spieker, T., Spira, M., Tattersall, J., Unel, G., Vega-Morales, R., Waltenberger, W., Weiler, A., You, T., Zapata, O. A., Zerwas, D.   +80 more
core   +3 more sources

Refactoring, reengineering and evolution: paths to Geant4 uncertainty quantification and performance improvement

, 2012
Ongoing investigations for the improvement of Geant4 accuracy and computational performance resulting by refactoring and reengineering parts of the code are discussed.
Batic, M., Begalli, M., Han, M., Hauf, S., Hoff, G., Kim, C. H., Kuster, M., Pia, M. G., Saracco, P., Seo, H., Weidenspointner, G., Zoglauer, A.   +11 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Computation in Classical Mechanics

, 2007
There is a growing consensus that physics majors need to learn computational skills, but many departments are still devoid of computation in their physics curriculum.
Cook David M., DeVries Paul L., Fowles Grant R., Garcia Alejandro L., Giordano Nicholas J., Hasbun Javier E., Javier E. Hasbun, Koonin Steven E., Landau Rubin H., Taylor John R., Thornton Stephen T., Todd Timberlake, Wong Samuel S. M.   +12 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Computation across the curriculum: What skills are needed?

, 2015
Computation, the use of a computer to solve, simulate, or visualize a physical problem, has revolutionized how physics research is done. Computation is used widely to model systems, to simulate experiments, and to analyze data. Yet, in most undergraduate
Caballero, Marcos D.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

HOW PHYSICISTS WASTE SUPERCOMPUTERS TIME IN ACADEMIC COMPUTER CENTER CYFRONET-KRAKOW

TASK Quarterly, 1998
In this paper computer facilities for scientific research groups in Cracow arc presented. Some problems solved by using supercomputers in Academic Computer Center Cyfronet-Krakow are discussed. The main flowcharts of computer algorithms and programs are
KRZYSZTOF MALARZ, ANDRZEJ Z. MAKSYMOWICZ, KRZYSZTOF KUŁAKOWSKI   +2 more
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