Results 21 to 30 of about 930,474 (234)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Numerical methods for computing Casimir interactions

open access: yes, 2010
We review several different approaches for computing Casimir forces and related fluctuation-induced interactions between bodies of arbitrary shapes and materials.
da Rosa, Felipe   +3 more
core   +1 more source

Statistical Challenges with Massive Data Sets in Particle Physics [PDF]

open access: yes, 2003
The massive data sets from today's particle physics experiments present a variety of challenges amenable to the tools developed by the statistics community.
Knuteson, Bruce, Padley, Paul
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Computational Nuclear Physics and Post Hartree-Fock Methods

open access: yes, 2016
We present a computational approach to infinite nuclear matter employing Hartree-Fock theory, many-body perturbation theory and coupled cluster theory.
A. Baran   +61 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu   +11 more
wiley   +1 more source

Coming home from a MOOC

open access: yes, 2014
My ten-week Massive Open Online Course "Statistical Mechanics: Algorithms and Computations", in early 2014, focused on subjects such as Monte Carlo sampling, molecular dynamics, transition phases in hard-sphere liquids, simulated annealing, classical ...
Krauth, Werner
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Computability and Physical Theories [PDF]

open access: yesFoundations of Physics, 1986
The familiar theories of physics have the feature that the application of the theory to make predictions in specific circumstances can be done by means of an algorithm. We propose a more precise formulation of this feature --- one based on the issue of whether or not the physically measurable numbers predicted by the theory are computable in the ...
Geroch, Robert, Hartle, James B.
openaire   +2 more sources

Understanding Student Computational Thinking with Computational Modeling

open access: yes, 2012
Recently, the National Research Council's framework for next generation science standards highlighted "computational thinking" as one of its "fundamental practices".
Aiken, John M.   +6 more
core   +1 more source

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