Results 51 to 60 of about 457,254 (250)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

GEANT4 : a simulation toolkit [PDF]

, 2002
Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits.
Arce, P., Tanaka, S., Rybin, A., Degtyarenko, P., Brunengo, A., Sulkimo, J., Chytracek, R., Garelli, S., Pia, M.G., Boudreau, J., Stoecker, H., Agostinelli, S., Asai, M., Burkhardt, H., Araujo, H., Takahata, M., Grichine, V., Zschiesche, D., González, I., Yamada, T., Scherer, Stefan, Lamanna, E., Cosmo, G., Starkov, N., Wander, W., Tropeano, M., Kawabata, M., Kodama, Takeshi, Ohtsubo, K., Tcherniaev, E., Kimura, Atsushi, Lefebure, V., Behner, F., Longo, F., Truscott, P., Jones, F.W., Wellisch, J.P., O'Neale, S., Banerjee, S., Depaola, G., Liendl, M., Urban, P., Feliciello, Alessandro, Chauvie, S., Kanaya, N., Pfeiffer, Andreas, Foppiano, F., Weber, H., Paech, K., Ranjard, F., Allison, J., Greeniaus, G., Nishimura, T., Uno, H., Hasui, H., Greiner, W., Giani, S., Guatelli, S., Hashimoto, K., Nieminen, P., Kodama, T., Sirotenko, V., Okamura, M., Safai Tehrani, E., Kelner, S., Ferguson, C., Kawaguti, M., Pfeiffer, A., Howard, A., Smith, D., Greiner, Walter, Kallenbach, J., Kossov, M., Sadilov, S., Minamimoto, K., Lei, F., Williams, D.C., Yoshida, H., Verderi, M., Kawabata, Y., Axen, D., Gracia Abril, G., Ivanchenko, V., Fesefeldt, H., Heikkinen, A., O’Neale, S., Kokoulin, R., Lara, V., Folger, G., Dell’Acqua, A., Gómez Cadenas, J.J., Maire, M., Kurashige, H., Nagamatu, M., Dietrich, D., Enami, R., Sawada, Y., Scherer, S., Giannitrapani, R., Medernach, E., Amako, K., Chuma, J., Santin, G., Broglia, L., Sei, S., Nartallo, R., Apostolakis, J., Urban, L., Barrand, G., Magni, S., Dell'Acqua, A., Wenaus, T., Stöcker, Horst, Wright, D., Morita, Y., Lockman, W., Gumplinger, P., Bellagamba, L., Savvas, N., Mora de Freitas, P., Di Salvo, E., Oohata, Y., Perl, J., Cooperman, G., Hamatsu, R., Gibin, D., Kent, P., Feliciello, A., Murakami, K., Grossheim, A., Walkden, A., Forti, A., Johnson, A., Kimura, A., Lampén, T., Sasaki, T., Ferguson, C, Chernyaev, E, S. Sadilov, Lara, V, L. Broglia, G. Barrand, Nagamatu, M, Kokoulin, R P, Foppiano, F, J. Allison, Giani, S, D. Smith, L. Bellagamba, Kallenbach, Jeff, M. Okamura, R. Hamatsu, W. Wander, Rybin, A, Dueñas D., A. Dell'Acqua, F. Longo, O'Ohata, Y, G. Greeniaus, M. Kawabata, Tapia A., L. Urban, P. Urban, Verderi, M, F. Foppiano, P. Truscott, K. Minamimoto, A. Pfeiffer, A. Feliciello, F. Lei, Tropeano, M, Dietrich, D D, Santin, G, S. Kelner, Morita, Y, M.G. Pia, A. Grossheim, A. Walkden, Mora de Freitas, P, G. Depaola, Truscott, P R, S. Scherer, H. Yoshida, P. Mora de Freitas, Grossheim, A, Heikkinen, A M, R. Nartallo, F. Ranjard, Johnson, A, D. Axen, T. Sasaki, GIBIN, DANIELE, D. Wright, A. Brunengo, Sirotenko, V I, S. Banerjee, Sadilov, S, Pfeiffer, A, S. Sei, Urbàn, L, Kelner, S, Allison, J, J. Kallenbach, H. Kurashige, Feliciello, A, Kossov, M, Nartallo, R, H. Burkhardt, H. Fesefeldt, Jones, F. W., Garelli, S, Takahata, M, Perl, J, G. Gracia Abril, T. Kodama, P. Arce, Okamura, M, Amako, K, Medernach, E, Apostolakis, John, K. Paech, Williams, D C, S. Guatelli, Grichine, V M, Cooperman, G, Seil, S., Cosmo, G, A. Kimura, S. Giani, Boudreau, J, J. Apostolakis, Hasui, H, M. Kossov, N. Kanaya, Savvas, N, Nieminen, P, Gibin, D, K. Ohtsubo, Lockman, W, D. C. Williams, D.C. Williams, E. Di Salvo, J.J. Gómez Cadenas, N. Starkov, S. Tanaka, P. Kent, M. G. Pia, Wander, W, H. Hasui, Maire, M, Sawada, Y, Ranjard, F, Ossa Varón, Santiago, K. Hashimoto, Pia, M. G., Axen, D A, Agostinelli, S, Ivanchenko, V N, Bellagamba, L, R. Giannitrapani, M. Maire, Zschiesche, D, Murakami, K, F. Behner, Giannitrapani, R, F. W. Jones, P. Gumplinger, Lamanna, E, Hashimoto, K, Y. Sawada, Behner, F, J. J. Gómez Cadenas, Tanaka, S, Kawaguti, M, González, I, Minamimoto, K, Lei, F, Sasaki, T, Forti, A C, Cadenas, J. J. G., Degtyarenko, P V, Greeniaus, L G, Pia, M G, P. Nieminen, S. Garelli, K. Amako, H. Stoecker, M. Tropeano, De Paola, G O, F.W. Jones, E. Safai Tehrani, D. Dietrich, A. Howard, Hutton, A M, Jones, F W, V. Lefebure, W. Greiner, D. Gibin, S. Magni, Broglia, L, M. Verderi, Y. Kawabata, Safai-Tehrani, F, J. Perl, Kent, P, Caicedo D.A.M., Wellisch, J. P., Y. Oohata, S. O'Neale, Lampen, T, J.P. Wellisch, Arce, P, M. Asai, S. Chauvie, Wright, D, Sei, S, Howard, A, G. Folger, D. Zschiesche, V. Lara, Kodama, T, V. Grichine, Rodriguez J., Barrand, G, O'Neale, Stephen, J. Chuma, Enami, R, K. Murakami, Urban, P, C. Ferguson, I. González, Kanaya, N, Scherer, S, Dell'Acqua, A, M. Liendl, Greiner, W, Kawabata, M, Fesefeldt, H S, Yoshida, H, W. Lockman, E. Medernach, A. Heikkinen, Kawabata, Y, H. Araujo, Chauvie, S, Nishimura, T, Asai, M, Brunengo, A, M. Kawaguti, G. Santin, A. Forti, Smith, D, R. Enami, Gómez-Cadenas, J J, Kurashige, H, O'Neale, S W, Hamatsu, R, Mecking, B A, Tehrani, E. S., Banerjee, S, Longo, F, Wellisch, J P, H. Weber, Liendl, M, V. Sirotenko, T. Lampén, Stöcker, H, Araújo, H M, de Freitas, P. M., Magni, S, Weber, H, Gracía-Abríl, G, Abril, G. G., A. Johnson, Y. Morita, A. Rybin, Lefébure, V, Chytracek, R, R. Chytracek, T. Yamada, N. Savvas, T. Nishimura, Wenaus, T, Williams, D. C., J. Sulkimo, E. Tcherniaev, Di Salvo, E, P. Degtyarenko, J. Boudreau, Walkden, A, E. Lamanna, Burkhardt, Hans, M. Takahata, Yamada, T, Sulkimo, J, J. P. Wellisch, R. Kokoulin, G. Cosmo, Folger, G, Ohtsubo, K, H. Uno, Starkov, N, G. Cooperman, M. Nagamatu, V. Ivanchenko, T. Wenaus, Betancourt J., Uno, H, Chuma, J, S. Agostinelli, Gumplinger, P   +410 more
core   +2 more sources

Intuitive tests to validate machine learning models against physics and domain knowledge

Digital Engineering
The integration of machine learning (ML) faces a fundamental challenge because current explainability methods provide statistical attribution and lack systematic frameworks for validating explanations against physical laws, constitutive relationships ...
M.Z. Naser
doaj   +1 more source

All superconducting tokamak: EAST

AAPPS Bulletin, 2023
Experimental Advanced Superconducting Tokamak (EAST) was built to demonstrate high-power, long-pulse operations under fusion-relevant conditions, with major radius R = 1.9 m, minor radius a = 0.5 m, and design pulse length up to 1000s.
Jiansheng Hu, Weibin Xi, Jian Zhang, Liansheng Huang, Damao Yao, Qing Zang, Yanlan Hu, Guizhong Zuo, Qiping Yuan, Jinping Qian, Zhiwei Zhou, Xinjun Zhang, Mao Wang, Handong Xu, Yahong Xie, Zhengchu Wang, Haiqing Liu, Youwen Sun, Liang Wang, Guoqiang Li, Hongxing Yin, Yao Yang, Xianzu Gong, Kun Lu, Guosheng Xu, Junling Chen, Fukun Liu, Jiangang Li, Yuntao Song, the EAST team   +29 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Why female science, technology, engineering, and mathematics majors do not identify with physics: They do not think others see them that way

Physical Review Physics Education Research, 2019
Gender differences in students’ physics identity in introductory physics courses can influence students’ interest in science, technology, engineering, and mathematics and their career decisions. Exploring the components that influence these identities is
Z. Yasemin Kalender, Emily Marshman, Christian D. Schunn, Timothy J. Nokes-Malach, Chandralekha Singh   +4 more
doaj   +1 more source

Splits in students’ beliefs about learning classical and quantum physics

International Journal of STEM Education, 2019
Background While there has been increasing recognition of the importance of attending to students’ views about what counts as knowing and learning a STEM field, surveys that measure these “epistemological” beliefs are often used in ways that implicitly ...
Benjamin W. Dreyfus, Jessica R. Hoehn, Andrew Elby, Noah D. Finkelstein, Ayush Gupta   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Subsystem functionals and the missing ingredient of confinement physics in density functionals [PDF]

, 2010
The subsystem functional scheme is a promising approach recently proposed for constructing exchange-correlation density functionals. In this scheme, the physics in each part of real materials is described by mapping to a characteristic model system. The “
Ann E. Mattsson, Armiento, Rickard,, Rickard Armiento, Hao, Feng,, Mattsson, Ann E.,, Feng Hao, Hao, Feng, Armiento, Rickard, Armiento, Rickard R., Mattsson, Ann E.   +9 more
core   +1 more source