Results 31 to 40 of about 293,038 (215)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

ENTREVISTA CON ESPERANZA AGUILAR DE FLÓREZ [PDF]

Gondola, 2011
Brief biography:Degree in Physics at Industrial University of Santander, Colombia. Master in Education, and Master in Physics at Industrial University of Santander. She has served as professor at UIS for 32 years.
OLGA LUCIA CASTIBLANCO ABRIL
doaj  

Hybrid Courses Based on Basic Sciences and Green Technologies in Engineering Programs

Engineering Proceedings, 2023
An ineluctable topic has emerged and needs to be treated in engineering programs for green energies. Particularly in the programs of electrical and systems engineering, students can acquire the capabilities to envision the arrival of green standards to ...
Huber Nieto-Chaupis
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Physics for future doctors: bridging physics, medicine, and engineering through a multiversity initiative

Frontiers in Education
IntroductionTraditional physics education has not always aligned with the interests and perceived needs of pre-medical and health science students due to a lack of perceived clinical relevance, leading to disengagement and shallow conceptual ...
Muhammad Nafees, Sami El-Borgi, Shameel Abdulla, Muhammad Hanif, Rachid Bendriss, Mohammad S. Yousef   +5 more
doaj   +1 more source

All superconducting tokamak: EAST

AAPPS Bulletin, 2023
Experimental Advanced Superconducting Tokamak (EAST) was built to demonstrate high-power, long-pulse operations under fusion-relevant conditions, with major radius R = 1.9 m, minor radius a = 0.5 m, and design pulse length up to 1000s.
Jiansheng Hu, Weibin Xi, Jian Zhang, Liansheng Huang, Damao Yao, Qing Zang, Yanlan Hu, Guizhong Zuo, Qiping Yuan, Jinping Qian, Zhiwei Zhou, Xinjun Zhang, Mao Wang, Handong Xu, Yahong Xie, Zhengchu Wang, Haiqing Liu, Youwen Sun, Liang Wang, Guoqiang Li, Hongxing Yin, Yao Yang, Xianzu Gong, Kun Lu, Guosheng Xu, Junling Chen, Fukun Liu, Jiangang Li, Yuntao Song, the EAST team   +29 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source