Results 41 to 50 of about 1,664,258 (279)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

ENTREVISTA CON ESPERANZA AGUILAR DE FLÓREZ [PDF]

Gondola, 2011
Brief biography:Degree in Physics at Industrial University of Santander, Colombia. Master in Education, and Master in Physics at Industrial University of Santander. She has served as professor at UIS for 32 years.
OLGA LUCIA CASTIBLANCO ABRIL
doaj  

All superconducting tokamak: EAST

AAPPS Bulletin, 2023
Experimental Advanced Superconducting Tokamak (EAST) was built to demonstrate high-power, long-pulse operations under fusion-relevant conditions, with major radius R = 1.9 m, minor radius a = 0.5 m, and design pulse length up to 1000s.
Jiansheng Hu, Weibin Xi, Jian Zhang, Liansheng Huang, Damao Yao, Qing Zang, Yanlan Hu, Guizhong Zuo, Qiping Yuan, Jinping Qian, Zhiwei Zhou, Xinjun Zhang, Mao Wang, Handong Xu, Yahong Xie, Zhengchu Wang, Haiqing Liu, Youwen Sun, Liang Wang, Guoqiang Li, Hongxing Yin, Yao Yang, Xianzu Gong, Kun Lu, Guosheng Xu, Junling Chen, Fukun Liu, Jiangang Li, Yuntao Song, the EAST team   +29 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Physics for future doctors: bridging physics, medicine, and engineering through a multiversity initiative

Frontiers in Education
IntroductionTraditional physics education has not always aligned with the interests and perceived needs of pre-medical and health science students due to a lack of perceived clinical relevance, leading to disengagement and shallow conceptual ...
Muhammad Nafees, Sami El-Borgi, Shameel Abdulla, Muhammad Hanif, Rachid Bendriss, Mohammad S. Yousef   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Scanning electron microscopy of cold gases

, 2015
Ultracold quantum gases offer unique possibilities to study interacting many-body quantum systems. Probing and manipulating such systems with ever increasing degree of control requires novel experimental techniques. Scanning electron microscopy is a high
Ott, Herwig, Santra, Bodhaditya
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Intuitive tests to validate machine learning models against physics and domain knowledge

Digital Engineering
The integration of machine learning (ML) faces a fundamental challenge because current explainability methods provide statistical attribution and lack systematic frameworks for validating explanations against physical laws, constitutive relationships ...
M.Z. Naser
doaj   +1 more source