Results 71 to 80 of about 865,236 (332)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD

NeuroImage, 2022
Quantitative BOLD (qBOLD) MRI permits noninvasive evaluation of hemodynamic and metabolic states of the brain by quantifying parametric maps of deoxygenated blood volume (DBV) and hemoglobin oxygen saturation level of venous blood (Yv), and along with a ...
Hyunyeol Lee, Felix W Wehrli
doaj  

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

The Physiology of Ventilation [PDF]

Respiratory Care, 2014
The diffusion of gases brings the partial pressures of O2 and CO2 in blood and alveolar gas to an equilibrium at the pulmonary blood-gas barrier. Alveolar PCO2 (PACO2) dependson the balance between the amount of CO2 being added by pulmonary blood and the amount being eliminated by alveolar ventilation (V ̇ A).
Murias, G, Blanch, L, LUCANGELO, UMBERTO
openaire   +3 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The human gut microbiome and aging

Gut Microbes
The composition of the human gut microbiome has been observed to change over the course of an individual’s life. From birth, it is shaped by mode of delivery, diet, environmental exposures, geographic location, exposures to medications, and by aging ...
Evan Bradley, John Haran
doaj   +1 more source

The utilization spectrum of cardiac output monitoring devices among anesthesiology programs across Veterans Health Administration in the United States

Annals of Cardiac Anaesthesia, 2019
Background: Electronic monitoring of physiologic variables has gained widespread support over the past decade for critical patients in the intensive care setting.
Jahan Porhomayon, Leili Pourafkari, Ata Mahmoodpoor, Nader D Nader   +3 more
doaj   +1 more source

Biomarkers of Aging: From Primitive Organisms to Man [PDF]

, 2001
What biological changes take place as we age? Efforts by scientists to uncover the biomarkers of aging, that is, the normal phenomena of growing old, and to separate these inevitable physiologic changes from diseases and other factors.Warns that alleged "
Richard L. Sprott, Robert N. Butler
core  

Impact of a Workplace Stress Reduction Program on Blood Pressure and Emotional Health in Hypertensive Employees [PDF]

, 2003
This study examined the impact of a workplace-based stress management program on blood pressure (BP), emotional health, and workplace-related measures in hypertensive employees of a global information technology ...
Dana Tomasino, Mike Atkinson, Rollin McCraty   +2 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source