Results 61 to 70 of about 341,332 (313)

Early Physiological and Neurological Monitoring after Traumatic Brain Injury as Foundations for Outcome Prediction: A Narrative Review

Bali Journal of Anesthesiology
Early physiological and neurological monitoring provides the first opportunity to identify and modify the determinants of outcome after traumatic brain injury.
Christopher Ryalino, Andrea Gentile, Putu Herdita Sudiantara, Tjokorda Gde Bagus Mahadewa   +3 more
doaj   +1 more source

A Physiologically-Based Pharmacokinetic Simulation to Evaluate Approaches to Mitigate Efavirenz-Induced Decrease in Levonorgestrel Exposure with a Contraceptive Implant

Pharmaceutics
Background: Levonorgestrel implant is a highly effective hormonal contraceptive, but its efficacy may be compromised when used with cytochrome enzyme inducers such as efavirenz. The primary aim of this study was to evaluate methods of mitigating the drug
Lilian W. Adeojo, Rena C. Patel, Nancy C. Sambol   +2 more
doaj   +1 more source

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Molecules, 2021
Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski   +10 more
doaj   +1 more source

Systemic and brain physiologic parameters.

, 2016
Systemic and brain physiologic parameters.
J. Michael Schmidt (444670), David Albers (785167), Sachin Agarwal (444672), Soojin Park (516759), Hans-Peter Frey (2635864), Cristina Maria Falo (2635867), Samantha Kleinberg (2635870), Yuxiao Huang (2635861), Jan Claassen (444674), E. Sander Connolly (2635876), Shah Atiqur Rahman (2635873)   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Hemodynamic monitoring and Physiologic Parameters

, 2016
Hemodynamic monitoring and Physiologic ...
Xiao-Qian Li (3228444), Xi-Jia Sun (3228441), Zai-Li Zhang (3228435), Sun, Xi-Jia, Wen-Fei Tan (3228438), Hong Ma (48973), Ma, Hong, Zhang, Zai-Li, Li, Xiao-Qian, Tan, Wen-Fei   +9 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Clinical and Translational Medicine, 2021
Hermansky–Pudlak syndrome (HPS) is a rare genetic disorder which, in its most common and severe form, HPS‐1, leads to fatal adult‐onset pulmonary fibrosis (PF) with no effective treatment.
Resat Cinar, Joshua K. Park, Charles N. Zawatsky, Nathan J. Coffey, Steven P. Bodine, Jasmina Abdalla, Tadafumi Yokoyama, Tony Jourdan, Lindsey Jay, Mei Xing G. Zuo, Kevin J. O'Brien, Junfeng Huang, Ken Mackie, Asaf Alimardanov, Malliga R. Iyer, William A. Gahl, George Kunos, Bernadette R. Gochuico, May Christine V. Malicdan   +18 more
doaj   +1 more source

Estimation of physiologic ability and surgical stress score does not predict immediate outcome after pancreatic surgery

, 2011
The Estimation of Physiologic Ability and Surgical Stress score was designed to predict postoperative morbidity and mortality in general surgery.
Daniel Inderbitzin, Gloor, Beat, Deyle, Simone, Markus Wagner, Karin Becker, Inderbitzin, Daniel, Beat Gloor, Candinas, Daniel, Becker, Karin, Simone Deyle, Vanessa Martine Banz, Banz, Vanessa Martine, Wagner, Markus, Daniel Candinas   +13 more
core   +1 more source

Physiology of Mycobacteria [PDF]

, 2009
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection.
Cook, Gregory M., Berney, Michael, Gebhard, Susanne, Heinemann, Matthias, Cox, Robert A., Danilchanka, Olga, Niederweis, Michael   +6 more
openaire   +4 more sources