Results 71 to 80 of about 533,338 (305)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Estimulação calórica a ar em mastoidectomias abertas unilaterais Air caloric test in canal wall down mastoidectomy

Brazilian Journal of Otorhinolaryngology, 2012
Poucos trabalhos desde a década de 70 foram realizados a fim de elucidar a prova calórica em alterações da orelha média, apesar de inúmeras controvérsias que este exame pode trazer em estruturas anatômicas tão distintas.
Lucia Kazuko Nishino, Lidio Granato
doaj   +1 more source

More than a feeling: A unified view of stress measurement for population science. [PDF]

, 2018
Stress can influence health throughout the lifespan, yet there is little agreement about what types and aspects of stress matter most for human health and disease.
Crosswell, Alexandra D, Epel, Elissa S, Mayer, Stefanie E, Mendes, Wendy Berry, Prather, Aric A, Puterman, Eli, Slavich, George M   +6 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Early Physiological and Neurological Monitoring after Traumatic Brain Injury as Foundations for Outcome Prediction: A Narrative Review

Bali Journal of Anesthesiology
Early physiological and neurological monitoring provides the first opportunity to identify and modify the determinants of outcome after traumatic brain injury.
Christopher Ryalino, Andrea Gentile, Putu Herdita Sudiantara, Tjokorda Gde Bagus Mahadewa   +3 more
doaj   +1 more source

Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review. [PDF]

, 2016
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire
Huang, Alex S, Mohindroo, Chirayu, Weinreb, Robert N   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The utilization spectrum of cardiac output monitoring devices among anesthesiology programs across Veterans Health Administration in the United States

Annals of Cardiac Anaesthesia, 2019
Background: Electronic monitoring of physiologic variables has gained widespread support over the past decade for critical patients in the intensive care setting.
Jahan Porhomayon, Leili Pourafkari, Ata Mahmoodpoor, Nader D Nader   +3 more
doaj   +1 more source

Impact of a Workplace Stress Reduction Program on Blood Pressure and Emotional Health in Hypertensive Employees [PDF]

, 2003
This study examined the impact of a workplace-based stress management program on blood pressure (BP), emotional health, and workplace-related measures in hypertensive employees of a global information technology ...
Dana Tomasino, Mike Atkinson, Rollin McCraty   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source