Results 41 to 50 of about 355,578 (262)

Physiology of Mycobacteria [PDF]

open access: yes, 2009
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection.
Cook, Gregory M.   +6 more
openaire   +4 more sources

Physiologic, metabolic, and blood parameters.

open access: yes, 2018
Physiologic, metabolic, and blood parameters.
David Clark (738)   +9 more
core   +1 more source

Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved? [PDF]

open access: yes, 2014
Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients.
Pirbodaghi, Tohid   +3 more
core   +2 more sources

Physiologic RNA targets and refined sequence specificity of coronavirus EndoU. [PDF]

open access: yes, 2020
Coronavirus EndoU inhibits dsRNA-activated antiviral responses; however, the physiologic RNA substrates of EndoU are unknown. In this study, we used mouse hepatitis virus (MHV)-infected bone marrow-derived macrophage (BMM) and cyclic phosphate cDNA ...
Ancar, Rachel   +8 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Baseline epidemiologic and physiologic data.

open access: yes, 2017
Baseline epidemiologic and physiologic data.
Efrat Bloomrosen (3612254)   +10 more
core   +1 more source

Use of Physiologic Reasoning to Diagnose and Manage Shock States [PDF]

open access: yes, 2011
Shock states are defined by stereotypic changes in well-known physiologic parameters. While these well-known changes provide a convenient entry point into further evaluation of patients in shock or at risk for shock, use of such physiologic evaluation is
Geoffrey Lighthall
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Physiologic variability in the perinatal period. Origins, measurement, and applications.

open access: yes, 1999
Variability is inherent in all physiologic signals. This variability provides valuable clinical information or may confound physiologic measurements and the interpretation of results.
Dunster, K. R., Dunster, K R
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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