Results 91 to 100 of about 3,630,760 (297)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Kisspeptin and neurokinin B: roles in reproductive health
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adultreproductive function including the menstrual cycle, as well as mediating the symptoms of menopause.Infundibular kisspeptin neurons, which ...
Abbara, Ali +5 more
core +1 more source
Flash photolysis of caged compounds: casting light on physiological processes
, 1998 Photorelease of bioactive molecules from inactive precursors is a very powerful tool for the study of the molecular mechanisms underlying physiological processes as diverse as ionic channel modulation, exocytosis, phototransduction, ligand-receptor ...
Landò L +6 more
core +1 more source
Physiology in Perspective: The Importance of Integrative Physiology [PDF]
Physiology, 2017 “The doctor of the future will give no medicine, but will interest his (her) patients in the care of the human frame, in diet, and in the cause and prevention of disease.” This comment, attributed to Thomas Edison, presaged the modern concepts of managed health care, health ...
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2013 Background: Hyperglycemia has been implicated in the etiology of diabetic nephropathy, which typically leads to elevated albumin levels in the urine as a result of glomerular and tubular dysfunction.
Kelly, Darren J. +4 more
core
Physiology in Perspective: The Value of Integrative Physiology [PDF]
Physiology, 2017 Almost a year ago, I gained a close and personal appreciation for the value gained from an understanding of integrative physiology. Suddenly one morning, while on vacation, I was struck by a massive pulmonary embolism and experienced first hand the importance of the interaction between the ...
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source