Results 101 to 110 of about 806,968 (339)
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
Ecophysiological adaptations of the lichen genera pseudocyphellaria and sticta to south temperate rainforests [PDF]
, 1991 Temperate rainforests are a poorly researched habitat with respect to lichen ecophysiology in comparison to desert and polar regions. The evergreen, broadleaf forests provide a dim, moist environment that is relatively stable throughout the year. Lichens
Green, T.G. Allan, Lange, Otto L.
core +2 more sources
Physiological Adaptions to Acute Hypoxia
, 2022 When tissues are insufficiently supplied with oxygen, the environment is said to be hypoxic. Acute (exposures to) hypoxia can occur occupationally, within the scope of training and competitions or under pathological conditions. The increasing interest in acute exposure to altitude for training and research purposes makes it more important than ever to ...
openaire +4 more sources
Molecular Oncology, EarlyView.Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley +1 more source
Physiologic adaptations of the tubuloglomerular feedback system
Kidney International, 1990 Knowledge of the existence of a tubuloglomerular feedback system has been available for many years. Only recently, however, have tenable hypotheses and supporting experimental data become available which have served to provide details regarding the complex inner workings of this system. The facility for examining this integrated physiologic network has
Orjan W. Peterson +3 more
openaire +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Exercise and Training at Altitudes: Physiological Effects and Protocols
Revista Ciencias de la Salud, 2014 An increase in altitude leads to a proportional fall in the barometric pressure, and a decrease in atmospheric oxygen pressure, producing hypobaric hypoxia that affects, in different degrees, all body organs, systems and functions.
Olga Cecilia Vargas Pinilla
doaj +1 more source
Range-based techniques for discovering optimality and analyzing scaling relationships in neuromechanical systems [PDF]
, 2009 In this paper, a method for decoupling the neuromuscular function of a set of limbs from the role morphology plays in regulating the performance of an activity is introduced.
Bradly J. Alicea
core +2 more sources
A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications
Molecular Oncology, EarlyView.Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker +3 more
wiley +1 more source
LifeThe 4Rs of sports nutrition were proposed in recent years as an evidence-based framework to optimize post-exercise recovery within the context of allostasis.
Diego A. Bonilla +8 more
doaj +1 more source