Results 81 to 90 of about 860,227 (306)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Use of Myocardial Work in Athletes: A Novel Approach to Assess Cardiac Adaptations and Differentiate Physiological Remodeling from Pathology

Applied Sciences
Myocardial work (MW), derived from non-invasive pressure–strain loop (PSL) analysis, has recently emerged as a promising echocardiographic index for assessing left ventricular performance.
Simona Mega, Chiara Fossati, Andrea Segreti, Riccardo Cricco, Zlatan Lazarevic, Myriam Carpenito, Federica Coletti, Jacopo Valeri, Erika Lemme, Fabio Pigozzi, Francesco Grigioni   +10 more
doaj   +1 more source

Solving the woolly mammoth conundrum: amino acid 15N-enrichment suggests a distinct forage or habitat [PDF]

, 2015
Understanding woolly mammoth ecology is key to understanding Pleistocene community dynamics and evaluating the roles of human hunting and climate change in late Quaternary megafaunal extinctions. Previous isotopic studies of mammoths’ diet and physiology
Longstaffe, Fred J, Metcalfe, Jessica Z, Schwartz-Narbonne, Rachel, Zazula, Grant   +3 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Physiological responses of children with surgically corrected congenital heart disease during high-altitude trekking: an exploratory observational study

Frontiers in Pediatrics
BackgroundChildren with surgically corrected congenital heart disease (CHD) are often perceived as fragile and discouraged from engaging in physical activity, despite evidence that structured exercise improves functional capacity and quality of life ...
Kwang Ho Choi, Woong-Han Kim, Woong-Han Kim, Ja-Kyoung Yoon   +3 more
doaj   +1 more source

Physiology of man and animals in the Tenth Five-Year Plan: Proceedings of the Thirteenth Congress of the I. P. Pavlov All-Union Physiological Society [PDF]

Research in the field of animal and human physiology is reviewed. The following topics on problems of physiological science and related fields of knowledge are discussed: neurophysiology and higher nervous activity, physiology of sensory systems ...
Lange, K. A.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Screening shade-tolerant centipedegrass genotypes: Physiological and transcriptomic insights into shade adaptation mechanisms

Grass Research
Shade stress is a major constraint for the growth and performance of turfgrass in urban environments. To investigate shade tolerance mechanisms in centipedegrass (Eremochloa ophiuroides), we evaluated 16 genotypes under 66% and 99% shading for 18 d. CP11
Yiming Liu, Guodao Liu, Rongshu Dong, Yu Zhang, Hengfu Huan, Daogeng Yu, Wenqiang Wang, Zhibo Wang   +7 more
doaj   +1 more source

Multiparameter vision testing apparatus [PDF]

, 1975
Compact vision testing apparatus is described for testing a large number of physiological characteristics of the eyes and visual system of a human subject.
Homkes, R. J., Hunt, S. R., Jr., Poteate, W. B., Sturgis, A. C.   +3 more
core   +1 more source

07 Intern Assignment Biological Adaptations [PDF]

, 2020
WELCOME to WINDOWS on the INQUIRY CLASSROOM! You have landed on a piece of a National Science Foundation Project (DUE 1245730) directed by Professor Chris Bauer, Chemistry Department, University of New Hampshire.
Bauer, Christopher F.
core   +1 more source