Model of Predicting Psychosocial Adaptation to Disease According to Perceived Stress and Sense of Coherence with the Mediation Role of Health Promoting Behaviors in Patients with Irritable Bowel Syndrome [PDF]
مجله علوم پزشکی صدراIntroduction: Psychosomatic diseases disrupt patients’ mental order, leading to chronic psychological injuries. Consequently, this study aimed to investigate the mediating role of health-promoting behaviors in the relationship between perceived stress ...
Farzaneh Forouzanfar +4 more
doaj +1 more source
Natural Variation and Neuromechanical Systems [PDF]
, 2009 Natural variation plays an important but subtle and often ignored role in neuromechanical systems. This is especially important when designing for living or hybrid systems \ud which involve a biological or self-assembling component.
Alicea, Bradly
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
An endogenous crepuscular rhythm of rainbow trout (Salmo gairdneri) photomechanical movements [PDF]
, 1982 1. The position of the epithelial pigment and cones in the retina of Salmo gairdneri was determined during extended periods of darkness in fish entrained to both artificial and natural light/dark cycles. 2. An endogenous rhythm of such photomechanical
Douglas, R. H.
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Ecological-biological Aspects of Stipa krylovii Roshev Adaptation at the Initial Stages of Ontogenesis [PDF]
Journal of Stress Physiology & Biochemistry, 2016 Xerophytic cereal Stipa krylovii Roshev is interesting as a relic with extensive capabilities to adapt to severe climatic conditions of Eastern Zabaikal’ye, which allows it to occupy a vast areal.
N.S. Chistyakova +2 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Impact Of Spike-Frequency Adaptation On Balanced Network Dynamics [PDF]
, 2018 A dynamic balance between strong excitatory and inhibitory neuronal inputs is hypothesized to play a pivotal role in information processing in the brain.
Barranca, Victor J. +2 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source