Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Клиническая практикаPhysical activity is recognized as the most important non-medicinal tool for the prevention of cardiovascular diseases, however, the highest efficiency is demonstrated by the programs combining various types of physical load.
Abduragim R. Magomedov +12 more
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Adaptation shapes local cortical reactivity: from bifurcation diagram and simulations to human physiological and pathological responses [PDF]
, 2022 Anna Cattani +5 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
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Post-exercise Cold Water Immersion Effects on Physiological Adaptations to Resistance Training and the Underlying Mechanisms in Skeletal Muscle: A Narrative Review [PDF]
, 2021 Aaron C. Petersen, Jackson J. Fyfe
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Ecological-biological Aspects of Stipa krylovii Roshev Adaptation at the Initial Stages of Ontogenesis [PDF]
Journal of Stress Physiology & Biochemistry, 2016 Xerophytic cereal Stipa krylovii Roshev is interesting as a relic with extensive capabilities to adapt to severe climatic conditions of Eastern Zabaikal’ye, which allows it to occupy a vast areal.
N.S. Chistyakova +2 more
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Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Model of Predicting Psychosocial Adaptation to Disease According to Perceived Stress and Sense of Coherence with the Mediation Role of Health Promoting Behaviors in Patients with Irritable Bowel Syndrome [PDF]
مجله علوم پزشکی صدراIntroduction: Psychosomatic diseases disrupt patients’ mental order, leading to chronic psychological injuries. Consequently, this study aimed to investigate the mediating role of health-promoting behaviors in the relationship between perceived stress ...
Farzaneh Forouzanfar +4 more
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