Results 121 to 130 of about 116,414 (298)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The MEG21 Unified Model for Modern Electronic Games of the 21st Century based on Electroencephalography-controlled Brain-Computer Interface

Journal on Interactive Systems
The rapid advancement of Brain-Computer Interface (BCI) technology has facilitated its employment in non-clinical contexts, including games. Electroencephalography (EEG)-controlled games merge the benefits of both fields, as they can be employed in both
Gabriel Alves Mendes Vasiljevic, Leonardo Cunha de Miranda   +1 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Molecular Computing: from conformational pattern recognition to complex processing networks

, 1996
Natural biomolecular systems process information in a radically different manner than programmable machines. Conformational interactions, the basis of specificity and self-assembly, are of key importance.
Conrad, Michael, Zauner, Klaus-Peter
core  

A Physiological Computing System to Improve Human-Robot Collaboration by Using Human Comfort Index

, 2022
Fluent human-robot collaboration requires a robot teammate to understand, learn, and adapt to the human\u27s psycho-physiological state. Such collaborations require a physiological computing system that monitors human biological signals during human ...
Savur, Celal
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Editorial: Biomedical Signals for Human-Computer Interaction

Frontiers in Computer Science, 2021
Hugo Plácido da Silva, Nuno M. Garcia, Erin T. Solovey   +2 more
doaj   +1 more source

Physiological Signal-Based Affective Computing System: Device, Toolkit and Models [PDF]

Affective computing, the study and development of systems that can recognize and respond to human emotions, has significant implications for applications in healthcare, education, and human-computer interaction.
Fang, Ruijie
core  

Designing sonic interactions for implicit physiological computing [PDF]

, 2016
La interacción persona-ordenador (HCI) estudia la relación entre usuarios y sistemas computacionales. Sin embargo, se concentra primordialmente en el control explícito, mediante dispositivos como el teclado o el ratón.
Mealla Cincuegrani, Sebastián
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source