Results 131 to 140 of about 116,414 (298)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Computational Physiology

open access: yes, 2006
The junior research group (JRG) is active in the field of mathematical modelling and numerical analysis of multiscale problems for stochastic and deterministic systems, with a strong focus on applications to life sciences. The current projects are on conformation dynamics, hybrid modelling and pharmacokinetics.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Exploring Bio-Impedance Sensing for Intelligent Wearable Devices

open access: yesBioengineering
The rapid growth of wearable technology has opened new possibilities for smart health-monitoring systems. Among various sensing methods, bio-impedance sensing has stood out as a powerful, non-invasive, and energy-efficient way to track physiological ...
Nafise Arabsalmani   +3 more
doaj   +1 more source

Emotion Distribution Learning Based on Peripheral Physiological Signals

open access: yes, 2022
Emotion analysis based on peripheral physiological signals has attracted increasing attention recently in affective computing.
Shu, Yezhi   +5 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Systematic Literature Review of Modalities, Trends, and Limitations in Emotion Recognition, Affective Computing, and Sentiment Analysis

open access: yes
This systematic literature review delves into the extensive landscape of emotion recognition, sentiment analysis, and affective computing, analyzing 609 articles.
David Rondon   +8 more
core   +1 more source

Connecting Brains and Bodies: Applying Physiological Computing to Support Social Interaction

open access: yes, 2015
Physiological and affective computing propose methods to improve human–machine interactions by adapting machines to the users’ states. Recently, social signal processing (SSP) has proposed to apply similar methods to human–human interactions with the ...
Guillaume Chanel   +5 more
core   +1 more source

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