Results 141 to 150 of about 116,414 (298)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Advancing Physiological Methods for Human-Information Interaction [PDF]

open access: yes
With the advancement of pervasive technology, information interaction has become increasingly ubiquitous. In these diverse information access devices and interfaces, it is crucial to understand and improve the user experience during human-information ...
Boonprakong, Nattapat   +6 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

A multimodal stress detection dataset with facial expressions and physiological signals

open access: yes
Affective computing has garnered the attention and interest of researchers in recent years, as there is a need for AI systems to better understand and react to human emotions.
Sohrab, Fahad   +7 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

PhysiolComp Toolkit: Analysis and Design for a Physiological Computing Based Human-Computer Interaction Toolkit

open access: yes, 2015
人机交互技术与生理计算技术的结合成为计算机应用领域的一个重要方向.然而,基于生理计算的交互应用研究和开发过程普遍存在缺乏生理计算知识、硬件种类繁 杂、软件逻辑和平台复杂度高等难题,为此我们设计了一个生理计算交互工具箱PhysiolComp Tolkit,提出了生理计算交互逻辑的设计框架,定义了较为完善的交互信息处理流程以及组件设计方法,并且以该工具箱中手部动作和生理状态监测组件为例 深入讨论了交互组件的设计方法.研究人员可以使用PhysiolComp Toolkit方便地建立生理计算交互应用框架 ...
路璐   +5 more
core  

Connecting Brains and Bodies: Applying Physiological Computing to Support Social Interaction [PDF]

open access: yes, 2017
Physiological and affective computing propose methods to improve human-machine interactions by adapting machines to the users' states. Recently, social signal processing (SSP) has proposed to apply similar methods to human-human interactions with the ...
Mühl, Christian, Chanel, Guillaume
core  

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

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